Rosuvastatin Production Cost Reports

The report provides a detailed analysis essential for establishing a Rosuvastatin manufacturing plant. It encompasses all critical aspects necessary for Rosuvastatin production, including the cost of Rosuvastatin production, Rosuvastatin plant cost, Rosuvastatin production costs, and the overall Rosuvastatin manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Rosuvastatin production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Rosuvastatin is used to lower cholesterol (LDL) and triglycerides in the blood while increasing HDL. It inhibits a certain enzyme in the liver that produces cholesterol and, thus, lowers the risk of heart disease and strokes. It is used for treating various forms of hyperlipidemia, as well as to slow the development or progression of cardiovascular disease. It is utilized in the treatment of primary hyperlipidemia and mixed dyslipidemia. It is employed for managing homozygous familial hypercholesterolemia and primary dysbetalipoproteinemia. Rosuvastatin is used for primary prevention of cardiovascular disease as it lowers the incidence of major cardiovascular events like heart attacks, strokes, and coronary revascularization procedures.

The market for Rosuvastatin is driven by several key factors. Its use in lowering cholesterol in various diseases contributes to its growing demand.  Its use in managing various forms of hyperlipidemia makes it an important drug for treatment. Its utilization in treating hypercholesterolemia makes it a sought-after product. The increasing cases of cardiovascular diseases in the aging population and obesity make it a popular drug among healthcare providers. Awareness about the significance of cholesterol level maintenance, since higher levels cause coronary artery blockages leading to cardiovascular issues, has also contributed to its market. Overall, industrial Rosuvastatin procurement is influenced by its widespread use in lowering cholesterol levels to manage various lipid disorders and prevent cardiovascular diseases, along with increased awareness to avoid heart complications.

Raw Material for Rosuvastatin Production

According to the Rosuvastatin manufacturing plant project report, the key raw materials used in the production of Rosuvastatin include Methyl Ester-Ethyl Alcohol-Tetrahydrofuran-Dichloromethane-Calcium Acetate.

Manufacturing Process of Rosuvastatin

The extensive Rosuvastatin production cost report consists of the following major industrial manufacturing process:

1. From Methyl Ester, Ethyl Alcohol, Tetrahydrofuran, Dichloromethane, and Calcium Acetate: The manufacturing of Rosuvastatin is a multi-step process. First, methyl ester is reacted with a mixture of ethyl alcohol and tetrahydrofuran. After that, sodium hydroxide is added to the mixture and stirred. Then, the reaction mixture is reacted with water and dichloromethane and combined with calcium acetate, forming the calcium salt of Rosuvastatin. Finally, the product is separated and purified to obtain pure Rosuvastatin.

Rosuvastatin has a molecular formula of C22H28FN3O6S, and it has a molecular weight of approximately 481.54 g/mol. It is a white amorphous powder that readily dissolves in water and methanol, sparingly soluble in ethanol. It has a melting point of around 150-155°C and a log P value of 0.13, making it highly hydrophilic in nature. It is 20% bioavailable, with peak plasma concentrations achieved at about three to five hours. It has a volume of distribution close to 134 liters and is bound 90% to the albumin. It is metabolized around 10% and has an elimination half-life of around 19 hours. All these physical and chemical properties contribute to its ability to lower lipid levels and reduce cardiovascular risk.