Amitriptyline Production By Dehydration Via Grignard Reaction
Production Cost Report | Healthcare
Details: Germany - based plant Q1 2024 | From $ USD
This report proffers the thorough economics of amitriptyline production by dehydration via the Grignard reaction. The preparation begins with the chemical reaction between 10,11-dihydro-N, N-dimethyl-5H-dibenzo[a,d]cyclohepten-5-one with Grignard reagent (3-dimethylaminopropylmagnesium bromide) that results in the formation of a tertiary alcohol as an intermediate compound. The intermediate product is further dehydrated using hydrochloric acid to give amitriptyline as the end product.
Top Producers of Amitriptyline
- Vintage Labs
- Bayer AG
- Accord Healthcare
- Zydus Pharmaceuticals, Inc.
- Allergan
Feedstocks for Amitriptyline
Amitriptyline is an anti-depressant drug that is synthesized using 10,11-dihydro-N, N-dimethyl-5H-dibenzo[a,d]cyclohepten-5-one as well as Grignard Reagent as its primary feedstocks. The procurement of these feedstocks is impacted by different factors related to its market dynamics. Some of the major factors include the availability of raw materials, the production rate of the feedstocks, manufacturing costs, supply chain stability, and demand observed from the downstream industries. Other factors such as logistics, trade, and governmental policies also have an impact on the overall acquisition of amitriptyline in the chemical market.
The project economic analysis provided in the report discusses a Germany-based plant:
- Manufacturing Process
- Process Flow
- Material Flow
- Material Balance
- Raw Material and Product's Specifications
- Raw Material Consumption
- Product and Co-Product Generation
- Capital Investment
- Land and Site Cost
- Offsites/Civil Works
- Equipment Cost
- Auxiliary Equipment Cost
- Contingency
- Engineering and Consulting Charges
- Working Capital
- Variable Cost
- Raw Material
- Utilities
- Fixed Cost
- Labor Requirement & Wages
- Overhead Expenses
- Maintenance Charges
- Financing Costs
- Interest on Working Capital
- Interest on Loans
- Depreciation Charges
- General Sales and Admin Costs
- Production Cost Summary
Report Content
Key Process Information
Evaluation of significant technical parameters along with process descriptions such as:
- Consumption of Raw Material
- Product Creation
- Block Flow Diagram
- Description of the Manufacturing Facility
Utilities Consumption
Evaluation of utilities consumed during the entire process based on:
- Consumption per unit of product generated
- Utility cost split and share of each utility in the total cost
Process Flow Diagram
Representation of various operations involved including:
- Step-wise process
- Utility consumption in each operation
Capital Cost Analysis
In-depth analysis of costs involved in setting up a new manufacturing unit, including:
- Cost of Building a Process Unit
- Cost of Setting Up the Infrastructure
- Working Capital
- Commissioning & Start-Up of the Plant
Implementation Schedule
Time frame of the project design, which includes:
- Plant Start-Up
- Plant Construction
- Engineering Fundamentals
- Raw Material Procurement
Construction Cost Details
Detailed analysis of costs involved in the operation of various functional units in the process unit and infrastructure.
Operating Cost Analysis
Evaluation of costs associated with the production of the final product, namely:
- Procurement of Raw Materials
- Consumption of Utilities
- Fixed Costs
- Depreciation
Economic Analysis
Analysis of the way in which process economics are impacted by plant capacity.
- Construction Cost
- Working Capital
- Fixed and Variable Operating Costs
- Corporate Overhead
- Depreciation
Customized Analyses
Detailed cost estimates of any industrial plant depending on your requirements, including plant capacity and location as per the need.
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