Azithromycin Production Cost Breakup from Erythromycin A
Production Cost Report | Chemicals
This report provides an extensive cost evaluation of producing Azithromycin from Erythromycin A. This method of production involves the use of erythromycin A as the starting material for producing azithromycin as the product. This process is initiated by the conversion of erythromycin A into its oxime derivative to modify the lactone ring into an oxime-containing structure. Further, the oxime is treated with an alkyl or aryl sulfonyl chloride in a mixture of acetone, water, and sodium bicarbonate, which causes oxime to undergo Beckmann-type rearrangement and ring expansion that converts oxime into a 15-membered imino-ether ring. Further, the imino-ether ring opens up to form a lactam (a cyclic amide) under hydrating conditions, followed by reductive methylation of lactam by using formaldehyde and formic acid, which results in the formation of azithromycin as the final product.
The project economic analysis provided in the report discusses a Germany-based plant:
- Manufacturing Process
- Process Flow
- Material Flow
- Material Balance
- Raw Material and Product's Specifications
- Raw Material Consumption
- Product and Co-Product Generation
- Capital Investment
- Land and Site Cost
- Offsites/Civil Works
- Equipment Cost
- Auxiliary Equipment Cost
- Contingency
- Engineering and Consulting Charges
- Working Capital
- Variable Cost
- Raw Material
- Utilities
- Fixed Cost
- Labor Requirement & Wages
- Overhead Expenses
- Maintenance Charges
- Financing Costs
- Interest on Working Capital
- Interest on Loans
- Depreciation Charges
- General Sales and Admin Costs
- Production Cost Summary
Report Content
Key Process Information
Evaluation of significant technical parameters along with process descriptions such as:
- Consumption of Raw Material
- Product Creation
- Block Flow Diagram
- Description of the Manufacturing Facility
Utilities Consumption
Evaluation of utilities consumed during the entire process based on:
- Consumption per unit of product generated
- Utility cost split and share of each utility in the total cost
Process Flow Diagram
Representation of various operations involved including:
- Step-wise process
- Utility consumption in each operation
Capital Cost Analysis
In-depth analysis of costs involved in setting up a new manufacturing unit, including:
- Cost of Building a Process Unit
- Cost of Setting Up the Infrastructure
- Working Capital
- Commissioning & Start-Up of the Plant
Implementation Schedule
Time frame of the project design, which includes:
- Plant Start-Up
- Plant Construction
- Engineering Fundamentals
- Raw Material Procurement
Construction Cost Details
Detailed analysis of costs involved in the operation of various functional units in the process unit and infrastructure.
Operating Cost Analysis
Evaluation of costs associated with the production of the final product, namely:
- Procurement of Raw Materials
- Consumption of Utilities
- Fixed Costs
- Depreciation
Economic Analysis
Analysis of the way in which process economics are impacted by plant capacity.
- Construction Cost
- Working Capital
- Fixed and Variable Operating Costs
- Corporate Overhead
- Depreciation
Customized Analyses
Detailed cost estimates of any industrial plant depending on your requirements, including plant capacity and location as per the need.
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