Captopril Production By Acylation Reaction
Production Cost Report | Healthcare
Details: Germany - based plant Q2 2024 | From $ USD
This report proffers the thorough economics of captopril production by acylation reaction. The preparation of captopril is processed by the chemical reaction between I-proline and 3-acetylthio-2-methylpropionic acid chloride. Initially, proline or I-proline is derived from glutamate using enzymes Δ1-pyrroline-5-carboxylate (P5C) synthetase (P5CS) and P5C reductase (P5CR). It is then reacted with 3-acetylthio-2-methylpropionic acid chloride (obtained from 3-acetylthio-2-methylpropionic acid). The reaction leads to the acylation of I-proline and leads to the formation of captopril as the final product.
Top Producers of Captopril
- Accord Healthcare
- Par Pharmaceutical
- A-S Medication Solutions
- Apotex
- Baker Cummins
Feedstock for Captopril
Captopril is an angiotensin-converting enzyme inhibitor that is used as a medication. It is prepared by using I-proline and 3-acetylthio-2-methylpropionic acid chloride as its primary feedstock. The procurement of captopril is majorly dependent upon some factors, including the availability of its raw materials (such as glutamate for I-proline and 3-acetylthio-2-methylpropionic acid for 3-acetylthio-2-methylpropionic acid chloride), along with the logistics and distribution operations. Moreover, prominent aspects such as the demand observed for captopril in the pharmaceutical and medical industries, stability in the supply chain, variations in the production cost and market prices, as well as the governmental and economic policies altogether govern its procurement across various regions.
The project economic analysis provided in the report discusses a Germany-based plant:
- Manufacturing Process
- Process Flow
- Material Flow
- Material Balance
- Raw Material and Product's Specifications
- Raw Material Consumption
- Product and Co-Product Generation
- Capital Investment
- Land and Site Cost
- Offsites/Civil Works
- Equipment Cost
- Auxiliary Equipment Cost
- Contingency
- Engineering and Consulting Charges
- Working Capital
- Variable Cost
- Raw Material
- Utilities
- Fixed Cost
- Labor Requirement & Wages
- Overhead Expenses
- Maintenance Charges
- Financing Costs
- Interest on Working Capital
- Interest on Loans
- Depreciation Charges
- General Sales and Admin Costs
- Production Cost Summary
Report Content
Key Process Information
Evaluation of significant technical parameters along with process descriptions such as:
- Consumption of Raw Material
- Product Creation
- Block Flow Diagram
- Description of the Manufacturing Facility
Utilities Consumption
Evaluation of utilities consumed during the entire process based on:
- Consumption per unit of product generated
- Utility cost split and share of each utility in the total cost
Process Flow Diagram
Representation of various operations involved including:
- Step-wise process
- Utility consumption in each operation
Capital Cost Analysis
In-depth analysis of costs involved in setting up a new manufacturing unit, including:
- Cost of Building a Process Unit
- Cost of Setting Up the Infrastructure
- Working Capital
- Commissioning & Start-Up of the Plant
Implementation Schedule
Time frame of the project design, which includes:
- Plant Start-Up
- Plant Construction
- Engineering Fundamentals
- Raw Material Procurement
Construction Cost Details
Detailed analysis of costs involved in the operation of various functional units in the process unit and infrastructure.
Operating Cost Analysis
Evaluation of costs associated with the production of the final product, namely:
- Procurement of Raw Materials
- Consumption of Utilities
- Fixed Costs
- Depreciation
Economic Analysis
Analysis of the way in which process economics are impacted by plant capacity.
- Construction Cost
- Working Capital
- Fixed and Variable Operating Costs
- Corporate Overhead
- Depreciation
Customized Analyses
Detailed cost estimates of any industrial plant depending on your requirements, including plant capacity and location as per the need.
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