Itraconazole Production From bromomethyl dichlorophenyl dioxalane benzoate and 1H-1,2,4 triazole
Production Cost Report | Healthcare
Itraconazole Production Cost Breakup From bromomethyl dichlorophenyl dioxalane benzoate and 1H-1,2,4 triazole
Details: Germany - based plant Q2 2024 | From $ USD
This report entails the detailed cost evaluation of Itraconazole production from bromomethyl dichlorophenyl dioxalane benzoate, and 1H-1,2,4 triazole. The manufacturing process of itraconazole involves several stages. In the first stage, bromomethyl dichlorophenyl dioxalane benzoate, and 1H-1,2,4 triazole are combined in a reactor, followed by sodium hydroxide solution.
The mixture is heated for 8 hours, then cooled and potassium carbonate is added. After stirring and filtering, the solvent dimethyl formamide is distilled off, and water and toluene are added to the remaining mixture. The organic layer is washed and dried to produce a specific compound. In the subsequent stages, additional reactions are carried out to produce intermediate compounds. Finally, in the last stage, itraconazole is obtained, which is purified using solvents and carbon.
Top Manufacturers of Itraconazole
- Tianjin Lisheng Pharmaceutical
- Le Pu Pharmaceutical
- Honz Pharmaceutical
- Macleods
- anssen Pharmaceutica
- Mylan
Feedstock for Itraconazole
The major feedstock for itraconazole involves the compounds bromomethyl dichlorophenyl dioxalane benzoate, and 1H-1,2,4 triazole, along with other chemicals such as toluene and other compounds. The availability and cost of raw materials such as phenol, chloroform and formaldehyde are necessary for the manufacturing of dichlorophenyl dioxalane benzoate.
The price, demand, and cost fluctuations of these feedstocks chiefly govern the procurement of itraconazole. Moreover, maintaining a reliable and stable source is essential for pharmaceutical industries. Technological advancements influencing costs and improving efficacy further influence the procurement of itraconazole. Additionally, factors such as regulatory compliance and global economic conditions also play a role in shaping the procurement of itraconazole around the world.
The project economic analysis provided in the report discusses a Germany-based plant:
- Manufacturing Process
- Process Flow
- Material Flow
- Material Balance
- Raw Material and Product's Specifications
- Raw Material Consumption
- Product and Co-Product Generation
- Capital Investment
- Land and Site Cost
- Offsites/Civil Works
- Equipment Cost
- Auxiliary Equipment Cost
- Contingency
- Engineering and Consulting Charges
- Working Capital
- Variable Cost
- Raw Material
- Utilities
- Fixed Cost
- Labor Requirement & Wages
- Overhead Expenses
- Maintenance Charges
- Financing Costs
- Interest on Working Capital
- Interest on Loans
- Depreciation Charges
- General Sales and Admin Costs
- Production Cost Summary
Report Content
Key Process Information
Evaluation of significant technical parameters along with process descriptions such as:
- Consumption of Raw Material
- Product Creation
- Block Flow Diagram
- Description of the Manufacturing Facility
Utilities Consumption
Evaluation of utilities consumed during the entire process based on:
- Consumption per unit of product generated
- Utility cost split and share of each utility in the total cost
Process Flow Diagram
Representation of various operations involved including:
- Step-wise process
- Utility consumption in each operation
Capital Cost Analysis
In-depth analysis of costs involved in setting up a new manufacturing unit, including:
- Cost of Building a Process Unit
- Cost of Setting Up the Infrastructure
- Working Capital
- Commissioning & Start-Up of the Plant
Implementation Schedule
Time frame of the project design, which includes:
- Plant Start-Up
- Plant Construction
- Engineering Fundamentals
- Raw Material Procurement
Construction Cost Details
Detailed analysis of costs involved in the operation of various functional units in the process unit and infrastructure.
Operating Cost Analysis
Evaluation of costs associated with the production of the final product, namely:
- Procurement of Raw Materials
- Consumption of Utilities
- Fixed Costs
- Depreciation
Economic Analysis
Analysis of the way in which process economics are impacted by plant capacity.
- Construction Cost
- Working Capital
- Fixed and Variable Operating Costs
- Corporate Overhead
- Depreciation
Customized Analyses
Detailed cost estimates of any industrial plant depending on your requirements, including plant capacity and location as per the need.
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