Production Cost Report | Healthcare

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Ketoconazole Production Cost Breakup From Cis Tosylate and N-Acetyl-(4-Hydroxy phenyl) Piperazine

Details: Germany - based plant Q2 2024  | From $ USD

This report entails the detailed cost evaluation of ketoconazole production from Cis Tosylate and N-Acetyl-(4-Hydroxy phenyl) Piperazine. The manufacturing process of ketoconazole starts with the condensation reaction of Cis Tosylate and N-Acetyl-(4-Hydroxy phenyl) Piperazine in the presence of acetone dimethyl sulphoxide. This results in the formation of an enantiomer of ketoconazole. Methanol is then added, and the final compound ketoconazole is formed after which it is dried, sieved, blended, and packed.

Top Manufacturers of Ketoconazole

  • Almirall
  • Taro Pharmaceutical
  • Teva Pharmaceutical
  • Sandoz
  • J&j

Feedstock for Ketoconazole

The feedstock for ketoconazole majorly involves the two compounds that are Cis Tosylate and N-Acetyl-(4-Hydroxy phenyl) Piperazine along with some other compounds such as acetone dimethyl sulphoxide and methanol. The factors that chiefly govern the manufacturing of ketoconazole are the price, demand fluctuation, supply chain management, and logistics of these feedstocks. Additionally, factors like regulatory requirements, geopolitical tensions, and environmental concerns may also influence the procurement of ketoconazole globally.

The project economic analysis provided in the report discusses a Germany-based plant:

  • Manufacturing Process
    • Process Flow
    • Material Flow
    • Material Balance
  • Raw Material and Product's Specifications
    • Raw Material Consumption
    • Product and Co-Product Generation
    • Capital Investment
  • Land and Site Cost
    • Offsites/Civil Works
    • Equipment Cost
    • Auxiliary Equipment Cost
    • Contingency
    • Engineering and Consulting Charges
    • Working Capital
  • Variable Cost
    • Raw Material
    • Utilities
  • Fixed Cost
    • Labor Requirement & Wages
    • Overhead Expenses
    • Maintenance Charges
  • Financing Costs
    • Interest on Working Capital
    • Interest on Loans
  • Depreciation Charges
  • General Sales and Admin Costs
  • Production Cost Summary
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Report Content

Key Process Information

Evaluation of significant technical parameters along with process descriptions such as:

  • Consumption of Raw Material
  • Product Creation
  • Block Flow Diagram
  • Description of the Manufacturing Facility

Utilities Consumption

Evaluation of utilities consumed during the entire process based on:

  • Consumption per unit of product generated
  • Utility cost split and share of each utility in the total cost

Process Flow Diagram

Representation of various operations involved including:

  • Step-wise process
  • Utility consumption in each operation

Capital Cost Analysis

In-depth analysis of costs involved in setting up a new manufacturing unit, including:

  • Cost of Building a Process Unit
  • Cost of Setting Up the Infrastructure
  • Working Capital
  • Commissioning & Start-Up of the Plant

Implementation Schedule

Time frame of the project design, which includes:

  • Plant Start-Up
  • Plant Construction
  • Engineering Fundamentals
  • Raw Material Procurement

Construction Cost Details

Detailed analysis of costs involved in the operation of various functional units in the process unit and infrastructure.

Operating Cost Analysis

Evaluation of costs associated with the production of the final product, namely:

  • Procurement of Raw Materials
  • Consumption of Utilities
  • Fixed Costs
  • Depreciation

Economic Analysis

Analysis of the way in which process economics are impacted by plant capacity.

  • Construction Cost
  • Working Capital
  • Fixed and Variable Operating Costs
  • Corporate Overhead
  • Depreciation

Customized Analyses

Detailed cost estimates of any industrial plant depending on your requirements, including plant capacity and location as per the need.

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