Metolazone Production From 5-Chloro-2-Methylaniline
Production Cost Report | Healthcare
Details: Germany - based plant Q2 2024 | From $ USD
This report entails the detailed cost evaluation of metolazone production from 5-chloro-2-methylaniline. The preparation process of metolazone is initiated by the chemical reaction between 5-chloro-2-methylaniline and ethyl chloroformate that yields 5-chloro-N-ethoxycarbonyl-2-methylaniline. It is then further reacted with a mixture of chlorosulfonic acid and ammonia and produces 4-sulfonamido-5-chloro-N-ethoxycarbonyl-2-methylaniline.
The compound obtained is then oxidized and treated with potassium permanganate and forms 5-sulfonamido-4-chloro-N-ethoxycarbonyl anthranylic acid as an intermediate. The intermediate is then treated with thionyl chloride and then reacted with o-toluidine to produce 2-amino-5-aminosulfonyl-4-chloro-o-toluolbenzamide as the resultant product. Finally, the chemical reaction between the resultant and dimethylacetal acetic acid leads to the production of 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quina-zolinsulfonamide or metolazone as the end product.
Top Producers of Metolazone
- Mylan Pharmaceuticals
- Teva Pharmaceuticals
- Watson Laboratories
- Lannett
- Gd Searle
Feedstock for Metolazone
Metolazone is a chemical drug synthesized by using 5-chloro-2-methylaniline as its primary raw material. The procurement of metolazone is directly influenced by some major factors, including the availability of its raw material (including aniline, chlorine, methanol, etc., that is used for 5-chloro-2-methylaniline production), the stability in the supply chain, distribution, and trading activities, etc.
Other prominent factors including the variations in its production cost and market prices, along with its demand observed in the chemical and pharmaceutical industries, and governmental policies directly govern its procurement in the global market. Moreover, factors such as the financial condition and socioeconomic policies also add to the factors influencing its procurement.
The project economic analysis provided in the report discusses a Germany-based plant:
- Manufacturing Process
- Process Flow
- Material Flow
- Material Balance
- Raw Material and Product's Specifications
- Raw Material Consumption
- Product and Co-Product Generation
- Capital Investment
- Land and Site Cost
- Offsites/Civil Works
- Equipment Cost
- Auxiliary Equipment Cost
- Contingency
- Engineering and Consulting Charges
- Working Capital
- Variable Cost
- Raw Material
- Utilities
- Fixed Cost
- Labor Requirement & Wages
- Overhead Expenses
- Maintenance Charges
- Financing Costs
- Interest on Working Capital
- Interest on Loans
- Depreciation Charges
- General Sales and Admin Costs
- Production Cost Summary
Report Content
Key Process Information
Evaluation of significant technical parameters along with process descriptions such as:
- Consumption of Raw Material
- Product Creation
- Block Flow Diagram
- Description of the Manufacturing Facility
Utilities Consumption
Evaluation of utilities consumed during the entire process based on:
- Consumption per unit of product generated
- Utility cost split and share of each utility in the total cost
Process Flow Diagram
Representation of various operations involved including:
- Step-wise process
- Utility consumption in each operation
Capital Cost Analysis
In-depth analysis of costs involved in setting up a new manufacturing unit, including:
- Cost of Building a Process Unit
- Cost of Setting Up the Infrastructure
- Working Capital
- Commissioning & Start-Up of the Plant
Implementation Schedule
Time frame of the project design, which includes:
- Plant Start-Up
- Plant Construction
- Engineering Fundamentals
- Raw Material Procurement
Construction Cost Details
Detailed analysis of costs involved in the operation of various functional units in the process unit and infrastructure.
Operating Cost Analysis
Evaluation of costs associated with the production of the final product, namely:
- Procurement of Raw Materials
- Consumption of Utilities
- Fixed Costs
- Depreciation
Economic Analysis
Analysis of the way in which process economics are impacted by plant capacity.
- Construction Cost
- Working Capital
- Fixed and Variable Operating Costs
- Corporate Overhead
- Depreciation
Customized Analyses
Detailed cost estimates of any industrial plant depending on your requirements, including plant capacity and location as per the need.
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