Acotiamide Production Cost Reports

The report provides a detailed analysis essential for establishing an Acotiamide manufacturing plant. It encompasses all critical aspects necessary for Acotiamide production, including the cost of Acotiamide production, Acotiamide plant cost, Acotiamide production costs, and the overall Acotiamide manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Acotiamide production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Acotiamide is a novel class of drug that treats individuals with functional dyspepsia, many of whom experience discomfort or feelings of fullness after eating, by improving stomach function. It is a prokinetic agent and a member of salicylamides. It helps people with digestive problems feel better by accelerating the passage of food through the stomach. It relieves symptoms of hypomotility in the abdomen by regulating motility in the upper gastrointestinal tract.

The procurement of Acotiamide is influenced by its application in the pharmaceutical and medical industries for the treatment of functional dyspepsia. The rising cases of functional dyspepsia and related problems are increasing the demand for Acotiamide.

It demonstrated a significant improvement in overall symptoms of functional dyspepsia (FD), with a higher chance of symptom relief compared to a placebo, driving its demand in the FD treatment market. It successfully alleviates symptoms of postprandial distress syndrome (PDS), showing a better response than placebo treatments, which contributes to its growing adoption for PDS management. Its favorable safety profile, which has resulted in no significant adverse effects being reported, enhances its attractiveness among patients and healthcare professionals, which in turn amplifies its market presence.

Its market expansion is enhanced by ongoing research and development initiatives in the pharmaceutical sector, which are producing better formulations and greater accessibility for the drug. Overall, industrial Acotiamide procurement is influenced by its utilization in the pharmaceutical and medical industries, rising cases of dyspepsia and related problems, better efficacy than placebo, favorable safety profile, better formulations, research and development, technological advancements, and regulatory approvals.

Raw Material for Acotiamide Production

According to the Acotiamide manufacturing plant project report, the key raw material used in the production of Acotiamide includes 2,4,5-trimethoxybenzoic acid.

Manufacturing Process of Acotiamide

The extensive Acotiamide production cost report consists of the following major industrial manufacturing process:

• Production from 2,4,5-trimethoxybenzoic acid: The manufacturing process of Acotiamide starts with the reaction of the starting compound with SOCl2 to form 2,4,5-trimethoxybenzoyl chloride. The compound if acylated with 2-aminothiazole-4-carboxylic acid ethyl ester to give the corresponding amide. The 2-methoxy group of the amide is cleaved by treatment with pyridine hydrochloride to form the 2-hydroxybenzamide. Finally, this compound is reacted with N,N-diisopropylethanediamine to produce Acotiamide.

Acotiamide, commercially known as Acofide, is a white to off-white crystalline powder having the molecular formula C21H30N4O5S and a molecular weight of 450.6 g/mol. It is soluble in water and methanol. It has a water solubility of around 0.0191 mg/mL. It has a log P value of 3.12. The value of its dissociation constant, pKa, is in the range of 8.24-9.62. It has a melting point in the range of 149-153°C. It is a member of salicylamides used to treat functional dyspepsia and related disorders.