Actinomycin Production Cost Reports

The report provides a detailed analysis essential for establishing an Actinomycin D manufacturing plant. It encompasses all critical aspects necessary for Actinomycin D production, including the cost of Actinomycin D production, Actinomycin D plant cost, Actinomycin D production costs, and the overall Actinomycin D manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Actinomycin D production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Actinomycin D is a member of the actinomycin group that works as an effective anti-tumor agent and is used in the treatment of various cancers. It is used in cell culture experiments as a selection agent. It works as an inhibitor in DNA-dependent RNA synthesis, intercalating into double-stranded DNA and slowing down transcription.

Actinomycin D is used to treat Wilms' tumor, testicular cancer, gestational trophoblastic disease (GTD), sarcomas, and other types of cancer. It is used in research related to biological processes like Suppressing HIV replication, effects of inhibiting DNA-dependent RNA synthesis, and mechanisms of gene regulation and transcription. Actinomycin D is also used in treating certain skin conditions like psoriasis and as a component in medication for certain skin infections.

The procurement of Actinomycin D is driven by several key factors. It is widely used in the treatment of various cancers, including Wilms' tumor, testicular cancer, and gestational trophoblastic disease (GTD), making it a valuable chemotherapy drug. Its role as a selection agent in cell culture experiments and its ability to inhibit DNA-dependent RNA synthesis make it are vital component in molecular biology and cancer research.

It intercalates into DNA slowing down transcription and preventing RNA synthesis, further enhancing its utility in studying cellular processes. It is also applied in treating certain skin conditions like psoriasis and is included in medications for skin infections, contributing to its market.  The changes in its demand as an anti-cancer drug and its utilization in research and clinical applications, along with its production prices, market prices, and logistics, directly influence industrial Actinomycin D procurement globally.

Raw Material for Actinomycin D Production

According to the Actinomycin D manufacturing plant project report, the various raw materials used in the production of Actinomycin D include glucose-soybean meal-calcium carbonate-sodium chloride.

Manufacturing Process of Actinomycin D

The extensive Actinomycin D production cost report consists of the following major industrial manufacturing process:

• From include glucose, soybean meal, calcium carbonate and sodium chloride: The industrial manufacturing of actinomycin D involves several steps. First, Streptomyces sp. Av-R5 strain is separated from aloe vera roots. This strain is cultured to promote growth, and after that, it is optimized in a fermentation medium consisting of glucose, soybean meal, calcium carbonate, and sodium chloride. The process of fermentation lasts up to 10 days, during which Actinomycin D is produced. After fermentation, the broth is filtered, and Actinomycin D is extracted using organic solvents for purification. The antimicrobial activity of the purified Actinomycin D is evaluated against various pathogens.

Actinomycin D is a yellow-colored, amorphous powder having a chemical formula C62H86N12O16 and a molar mass of 1255.438 g·mol?¹. It is soluble in water and organic solvents. Actinomycin D has a phenoxazine core linked to two cyclic pentapeptides, including a quinonimine portion responsible for its biological activity. It exhibits bacteriostatic properties against gram-positive bacteria and is primarily utilized for its cytotoxic effects against cancer. It is sensitive to light and should be stored in dark conditions to maintain its stability and efficacy.