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Afamelanotide Production Cost Reports

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Last Updated: September, 2024

Vishakha Agrawal profile photo
Written ByVishakha Agrawal
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  • Executive Summary
  • Key Process Information
  • Variable Cost Breakdown
  • Conversion Cost Analysis
  • Capital Investment Analysis
  • Land and Site Cost Details
  • Construction Cost Breakdown
  • Equipment Cost Breakdown
  • Techno-Economic Parameters
  • Delivery Format
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  • Construction Cost Breakdown
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  • Executive Summary
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Product Overview

The report provides a detailed analysis essential for establishing an Afamelanotide production plant. It encompasses all critical aspects necessary for Afamelanotide production, including the cost of Afamelanotide production, Afamelanotide plant cost, Afamelanotide production costs, and the overall Afamelanotide production plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Afamelanotide production plant. These encompass production processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Afamelanotide is a medication used to treat phototoxicity in adults with a rare condition called erythropoietic protoporphyria (EPP), which causes severe pain and skin reactions when patients are exposed to sunlight. It works by stimulating the production of a pigment in the skin called melanin, which helps to protect the skin from the harmful effects of sunlight. It is a synthetic 13-amino acid peptide that is the first of its kind to mimic the effects of endogenous alpha-melanocyte-stimulating hormone (α-MSH).

The market for Afamelanotide is driven by its usage as a melanocortin-1 receptor agonist used for the treatment of erythropoietic protoporphyria in adults, which significantly promotes its demand in the pharmaceutical and medical industries. The widespread occurrence of phototoxicity due to erythropoietic protoporphyria is significantly increasing the demand for Afamelanotide. Additionally, the approval of the drug for the treatment of diseases apart from EPP, for instance, polymorphic light eruption, vitiligo, acne vulgaris, Hailey-Hailey disease, and solar urticaria enhance the market size. Moreover, the drug exhibits the efficacy of anti-inflammatory and this makes the drug a potential therapy for other photosensitive dermatological disorders which are unresponsive to other treatments, thus driving the demand. Overall, industrial Afamelanotide procurement is influenced by its application in the pharmaceutical and medical industries, rising cases of EPP, off-label uses, anti-inflammatory action, and regulatory approvals.

Raw Material for Afamelanotide Production

According to the Afamelanotide production plant project report, the key raw material used in the production of Afamelanotide includes Rink-Amide-AM-resin.

Production Process of Afamelanotide

The extensive Afamelanotide production cost report consists of the following major industrial production process:

  1. Production from Rink-Amide-AM-resin: The production process of Afamelanotide starts with the HMBA linker being installed under standard condensation conditions with the presence of HOBt and base DIC to form modified HMBA-Rink-Amide-AM-resin. The resulting compound undergoes hydroxy esterification with Fmoc-Val-OH to form an intermediate. The intermediate is treated with DBLK realized N-Fmoc deprotection, followed by a condensation reaction with Fmoc-Pro-OH to give another intermediate. Following the same procedure, Fmoc-Lys(Boc)-OH is used to synthesize the polypeptide chain Ac-Ser-Tyl-Ser-Nle-Glu(OtBu)-His(trt)-D-Phe-Arg(pdf)-Trp(Boc)-Gly-Lys(Boc)-Pro-Val-MBA-Rink- Amide-AM-resin. Finally, the resin undergoes pyrolysis, hydrolysis of the protecting group, and amide condensation to produce Afamelanotide.

Afamelanotide is commercially known as Scenesse. It has the molecular formula C78H111N21O19 and a molecular weight of 1646.8 g/mol. It has an estimated water solubility of 0.023 mg/mL. It has a log P value of -1.4. The value of its dissociation constant, pKa, is 3.46. It is a 13-amino acid peptide analog of the endogenous alpha-melanocyte-stimulating hormone (α-MSH). It differs from α-MSH by two amino acids, enhancing its binding affinity to the melanocortin-1 receptor (MC1R) and providing a longer biological half-life and increased potency. It is used to reduce pain and itching from exposure to light in individuals with X-linked and erythropoietic protoporphyria by promoting the formation of melanin in the skin.

Afamelanotide Production Cost Report

Afamelanotide Production Cost Reports

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Product Details

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Product Details

Particulars Details
Product Name Afamelanotide
Scope Production Process: Process Flow, Material Flow, Material Balance

Raw Material and Product Specifications: Raw Material Consumption, Product and Co-product Generation

Land and Site Cost: Offsites/Civil Works, Equipment Cost, Auxiliary Equipment Costs, Contingency, Engineering and Consulting Charges, Working Capital

Variable Cost: Raw Material, Utilities, Other Variable Costs

Fixed Cost: Labor Requirements and Wages, Overhead Expenses, Maintenance Charges, Other Fixed Costs

Financing Costs: Interest on Working Capital, Interest on Loans

Other Costs: Depreciation Charges, General Sales and Admin Cost
Currency US$ (Data can also be provided in the local currency)
Pricing and Purchase Options Basic: US$ 2499
Premium: US$ 3499
Enterprise: US$ 4799
Customization Scope The report can be customized as per the requirement of the customer
Post-Sale Analysts Report 10-12 weeks of post-purchase analyst support after report delivery for any queries from the deliverable
Delivery Format PDF and Excel format through email (editable version in PPT/Word format of the report can be also provided on special request)

How does our Afamelanotide Production Cost Report Provide Exhaustive Data and Extensive Insights?

At Procurement Resource, we not only focus on optimizing the should cost of production for Afamelanotide but also provide our clients with extensive intel and rigorous information on every aspect of the production process. By utilizing a comprehensive cost model, we help you break down expenses related to raw materials, labor, and technology, offering clear pathways to savings. We also assist in evaluating the capital expenditure (CAPEX) and operating expenses (OPEX), which are often measured as cost per unit of production, such as USD/MT, ensuring that your financial planning is aligned with industry benchmarks.

We offer valuable insights on the top technology providers, in-depth supplier database, and best manufacturers, helping you make informed decisions to improve efficiency. Additionally, we design the most feasible layout for your production needs, ensuring the entire process runs smoothly. By minimizing the cash cost of production, we ensure that you stay competitive while securing long-term profitability in the growing Afamelanotide market. Partnering with Procurement Resource guarantees that every aspect of your production is cost-efficient, advanced, and tailored to your specific requirements.

Key Questions Answered in This Report

  • What are the key requirements for setting up an Afamelanotide production plant?
  • How is Afamelanotide manufactured?
  • What is the process flow involved in producing Afamelanotide?
  • What are the raw material requirements and costs for producing Afamelanotide?
  • What is the total size of land required for setting up an Afamelanotide production plant?
  • What are the construction requirements for setting up an Afamelanotide production plant?
  • What are the machinery requirements for producing Afamelanotide?
  • What are the utility requirements and costs for producing Afamelanotide?
  • What are the manpower requirements for producing Afamelanotide?
  • What are the average salaries/wages of manpower working in an Afamelanotide production plant?
  • What are the packaging requirements and associated costs for Afamelanotide?
  • What are the transportation requirements and associated costs for Afamelanotide?
  • What are the capital costs for setting up an Afamelanotide production plant?
  • What are the operating costs for setting up an Afamelanotide production plant?
  • What should be the price of Afamelanotide?
  • What will be the income and expenditures for an Afamelanotide production plant?

About the Author

Vishakha Agrawal profile photo

Vishakha Agrawal

Lead - Social & Development Research

Delivering procurement intelligence and supply chain analytics across healthcare, FMCG, and chemicals sectors, with expertise in cost modeling, vendor mapping, and spend optimization to support data-driven sourcing decisions and procurement outcomes.

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