Aminopyrine Production Cost Reports

The report provides a detailed analysis essential for establishing an Aminopyrine manufacturing plant. It encompasses all critical aspects necessary for Aminopyrine production, including the cost of Aminopyrine production, Aminopyrine plant cost, Aminopyrine production costs, and the overall Aminopyrine manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Aminopyrine production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Aminopyrine or Aminophenazone is an anti-inflammatory agent that finds its applications in the pharmaceutical industry. It is used as an analgesic agent in alleviating minor aches, joint pains, and muscular pains in animals. It also finds its application as an antipyretic agent in the treatment of fever and inflammation in animals. It is also used in the 13C-aminopyrine demethylation blood test (ADBT) to assess liver function in dogs for identifying liver disease in dogs. It is sometimes used as a non-steroidal analgesic and anti-inflammatory drug for treating conditions such as rheumatism, neuritis, and severe colds in humans. However, its use has been significantly reduced or banned in many countries due to the risk of serious side effects.

The demand for Aminopyrine is mainly led by its application as an antipyretic and analgesic drug for relieving persistent fever and severe pain. Its application as a drug for the treatment of severe joint pains, muscle pain, and fever reduction in animals further enhances its demand in the veterinary medicine industry. Its limited use in human medicine as an antipyretic and antispasmodic agent to treat acute migraine attacks, rheumatism, and neuritis also contributes to its demand in the medical and pharmaceutical industries. Its involvement as a non-invasive method to measure cytochrome P-450 metabolic activity in liver function tests also fuels its demand in the medical and diagnostics industries. Aminopyrine has been banned or restricted in many countries due to its potential side effects, such as agranulocytosis. Therefore, compliance with regulatory standards is crucial in determining where and how Aminopyrine can be procured and used, which directly affects industrial Aminopyrine procurement. Ethical sourcing and environmental impacts also serve as major factors that impact the procurement strategies for a pharmaceutical product like Aminopyrine. Strict testing for purity and safety, adherence to pharmaceutical standards, and certification through audits are also crucial in determining procurement strategies.

Raw Material for Aminopyrine Production

According to the Aminopyrine manufacturing plant project report, the major raw material for Aminopyrine production includes 4-Aminoantipyrine.

Manufacturing Process of Aminopyrine

The extensive Aminopyrine production cost report consists of the following industrial manufacturing process:

• Production from 4-Aminoantipyrine: This method of production involves the synthesis of Aminopyrine by using 4-Aminoantipyrine as the starting material. The process starts by first dissolving 4-Aminoantipyrine in water and heating it to 50-60°C, followed by transferring the solution to a hydrogenation tank. Further, a nickel catalyst is added to the tank, followed by evacuating the tank and filling it with hydrogen. When the pressure reaches 0.245 MPa, hydrogen flow is stopped, and formaldehyde is added. The reaction propagates at 60-85°C until testing. Then, the obtained mixture is cooled, followed by separating the crystals and filtration to obtain crude aminopyrine. As the last step, the obtained product is refined by heating with ethanol and activated carbon, filtered, and cooled to crystallize the final product, followed by washing and drying to give aminopyrine as the desired product.

Aminopyrine exits in the form of odorless, white, leaf-like crystals or crystalline powder and has a slightly bitter taste. The compound starts degrading in the presence of sunlight but is stable in the air. The molecular formula of the compound is C13H17N3O. Its molecular mass is around 231.299 g/mol. The melting point and the boiling point of the compound are 107-109 °C and 373.38°C, respectively. The compound is generally stored in a refrigerator. Its solubility in water is 5.55 g/100 mL. The compound is compatible with strong oxidizing agents. The compound has a role as a non-steroidal anti-inflammatory drug and a non-narcotic analgesic. It is also known as aminophenazone or amidopyrine.