Amlodipine Production Cost Reports

The report provides a detailed analysis essential for establishing an Amlodipine manufacturing plant. It encompasses all critical aspects necessary for Amlodipine production, including the cost of Amlodipine production, Amlodipine plant cost, Amlodipine production costs, and the overall Amlodipine manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Amlodipine production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Amlodipine is a dihydropyridine calcium channel blocker that is used in the management of various disorders. It is a medication that helps to relax and widen blood vessels, making the heart pump blood easily. It is used to manage hypertension as it effectively reduces blood pressure.

It helps in alleviating symptoms of chronic stable angina and vasospastic angina by improving blood flow to the heart muscle. Amlodipine is used in Coronary Artery Disease as it decreases the risk of coronary revascularization procedures. Besides its primary use, Amlodipine also has some off-label uses in diabetic nephropathy, left ventricular hypertrophy, Raynaud phenomenon, and pulmonary arterial hypertension.

The procurement of Amlodipine is primarily driven by its efficiency in treating various cardiovascular disorders. Its ability to lower blood pressure and alleviate symptoms of chronic stable angina and vasospastic angina by improving blood flow to the heart muscle makes it an essential medication in healthcare. It is used in patients having coronary artery disease to decrease the risk of hospitalization and reduce the need for coronary revascularization procedures resulting in its growing demand.

Its potential off-label use in conditions such as diabetic nephropathy, left ventricular hypertrophy, Raynaud phenomenon, and pulmonary arterial hypertension may also influence its procurement in specific patient populations. The developments in its demand in managing hypertension, angina pectoris, and other off-label medical uses, along with its production prices, market prices, and logistics, directly influence industrial Amlodipine procurement in the global market.

Raw Material for Amlodipine Production

According to the Amlodipine manufacturing plant project report, the various raw materials used in the production of Amlodipine include Amino Benzyl alcohol-carbonyl compound-aldehydes or ketones.

Manufacturing Process of Amlodipine

The extensive Amlodipine production cost report consists of the following major industrial manufacturing process:

• From Amino Benzyl Alcohol, Carbonyl Compound, and Aldehydes or Ketones: The manufacturing process of Amlodipine involves several key steps. First, amino benzyl alcohol is condensed using a suitable carbonyl compound. After that, cyclization is achieved through a reaction using aldehydes or ketones that form a dihydropyridine ring. After the formation of the dihydropyridine structure, functionalization is done to introduce the 4-(2-chlorophenyl) group. The final product is then purified by crystallization or recrystallization methods to obtain pure Amlodipine. In this process optimization of reaction conditions is ensured to enhance yield and purity.

Amlodipine is a white crystalline powder having a melting point of around 200.57°C. Its molecular formula is C20H25ClN2O5, and it has a molecular weight of around 408.15 g/mol. It is slightly soluble in water and is more soluble in organic solvents like DMSO. Its IUPAC name is 3-ethyl 5-methyl 2-[(2-aminoethoxy) methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate. It has 2 hydrogen bond donors and 10 hydrogen bond acceptors, along with 10 rotatable bonds. It is stable under normal conditions but should be stored in a cool, dry place away from light.