Anastrozole Production Cost Reports

The report provides a detailed analysis essential for establishing an Anastrozole manufacturing plant. It encompasses all critical aspects necessary for Anastrozole production, including the cost of Anastrozole production, Anastrozole plant cost, Anastrozole production costs, and the overall Anastrozole manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Anastrozole production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Anastrozole is an FDA-approved hormone therapy that is primarily used in the medical and pharmaceutical industries. It is widely used as a medication for the treatment of breast cancer, particularly in postmenopausal women. Moreover, the compound is mainly employed for the treatment of receptor-positive breast cancer only in women who have stopped menstruating. Additionally, it is also employed as an adjuvant therapy in patients to prevent and reduce the risk of cancer recurrence.

The demand for Anastrozole is driven by its role as a highly potent and selective aromatase inhibitor for reducing estrogen levels in the body and inhibiting the growth of estrogen-dependent tumors, which significantly boosts its market growth. Moreover, its application as a frug for the treatment of hormone receptor-positive breast cancer in postmenopausal women further accentuates its demand in the medical and pharmaceutical industries. Furthermore, several crucial factors, including the availability and cost of raw materials like 3,5-bis(bromomethyl)toluene, etc., regulatory compliance and quality standards, supplier relationships, efficient distribution, and logistics, and the effect of advances in technology, globally influence industrial Anastrozole procurement.

Raw Material for Anastrozole

According to the Anastrozole manufacturing plant project report, the major raw material for Anastrozole production includes 3,5-Bis(bromomethyl)toluene.

Manufacturing Process of Anastrozole

The extensive Anastrozole production cost report consists of the following industrial manufacturing process:

1. Production from 3,5-bis(bromomethyl)toluene: This method of production is initiated with an SN2 displacement of 3,5-bis(bromomethyl)toluene by using potassium nitrile and tetrabutylammonium bromide as a phase transfer catalyst to produce a bis-nitrile compound. Further, the obtained bis-nitrile compound undergoes protonation in the presence of NaH, followed by methylation with methyl iodide to give bis-dimethyated compound. Then, the obtained compound is subjected to radical substitution, followed by the Wohl-Ziegler reaction by using N-bromosuccinamide and benzoyl peroxide as the radical initiator to give the benzylbromide compound. As the last step, the obtained benzylbromide undergoes SN2 displacement with sodium triazole, which results in the formation of anastrozole as the final product.

Anastrozole belongs to the class of triazoles and is an aromatase inhibitor. The molecular formula of the compound is C17H19N5, and its molar mass is 293.4 g/mol. The compound is also known as Arimidex. Moreover, the compound exists in the form of a white crystalline solid that dissolves in organic solvents, including ethanol, DMSO, THF, and dimethyl formamide (DMF). The density of the compound is 1.08 g/cm3, and it is generally stored at room temperature. Additionally, the melting point of the compound is 81-82°C, and its boiling point is 469.7°C. The solubility of the compound in water is 0.5 mg/mL at 25 °C.