Atenolol Production Cost Reports

The report provides a detailed analysis essential for establishing an Atenolol manufacturing plant. It encompasses all critical aspects necessary for Atenolol production, including the cost of Atenolol production, Atenolol plant cost, Atenolol production costs, and the overall Atenolol manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Atenolol production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Atenolol is a synthetic beta-1 selective blocker used to treat hypertension and chronic angina and to lower mortality in patients with known or suspected myocardial infarction. It is a second-generation β-1-selective adrenergic antagonist. It functions as a sympatholytic agent, xenobiotic, anti-arrhythmia medication, beta-adrenergic antagonist, and antihypertensive agent. Thus, it finds its application in the pharmaceutical and medical industries.

The procurement of Atenolol is influenced by its application in the pharmaceutical and medical industries as a beta blocker used to treat hypertension and related cardiovascular disorders. The need for Atenolol is increasing as cases of cardiovascular diseases are on the rise. It witnesses a significant demand from the aging population as they are more likely to be affected by cardiovascular disorders such as hypertension and myocardial infarction. It is used off-label to treat arrhythmias, prevent migraines, treat paroxysmal supraventricular tachycardia, alcohol withdrawal, thyrotoxicosis, prevent secondary myocardial infarction, and management of infantile hemangiomas.

Atenolol is also used as an alternative to propranolol. The American Academy of Neurology (AAN) suggests Atenolol as a treatment for episodic migraine, which increases its demand. Overall, the industrial Atenolol procurement is influenced by its application in the pharmaceutical and medical industries as a beta blocker used to treat cardiovascular disorders, the rising cases of cardiovascular disorders such as hypertension and myocardial infarction, the aging population, its off-label uses, wide range of applications, along with fewer side effects, cost-effectiveness, increasing healthcare awareness among individuals, research and development, and regulatory approvals.

Raw Material for Atenolol Production

According to the Atenolol manufacturing plant project report, the key raw material used in the production of Atenolol includes 4-hydroxyphenylacetamide.

Manufacturing Process of Atenolol

The extensive Atenolol production cost report consists of the following major industrial manufacturing process:

• Production from 4-hydroxyphenylacetamide: The manufacturing process of Atenolol starts with the reaction of 4-hydroxyphenylacetamide with epichlorohydrin in the presence of piperidine as the catalyst at ambient temperature. The mixture is cooled, the precipitate is filtered out and then reacted with methanol. The intermediate thus formed is recrystallized by using methanol. The recrystallized intermediate is reacted with isopropyl amine in the presence of methanol to produce Atenolol.

Atenolol, commercially known as Tenormin, is a white crystalline powder having the molecular formula C14H22N2O3 and a molecular weight of 266.34 g/mol. It has a melting point in the range of 158-160 °C. It dissolves in acetic acid and DMSO. It is easily soluble in methanol, sparingly soluble in 96% ethanol and chloroform, very marginally soluble in acetone and dioxane, and completely insoluble in acetonitrile and ethyl acetate. It has a log P value of 0.16. The value of its dissociation constant, pKa, is 9.58. Atenolol has an N-isopropyl substituent and a (4-carbamoylmethylphenoxy)methyl group at the 1-position. It is a selective Beta-1 blocker used to treat various cardiovascular disorders.