The report provides a detailed analysis essential for establishing an Azlocillin production plant. It encompasses all critical aspects necessary for Azlocillin production, including the cost of Azlocillin production, Azlocillin plant cost, Azlocillin production costs, and the overall Azlocillin production plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Azlocillin production plant.
These encompass production processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.
Azlocillin is an antibiotic effective in treating infections caused due to Pseudomonas aeruginosa, Escherichia coli and Haemophilus influenzae. Further, it is synergistic with aminoglycosides against Ps. pseudomonas aeruginosa, specific enterobacteriacae and enterococci. It functions as an antibacterial drug. It has its origin from penicillin. It is penicillin based but not natural, commonly referred to as semisynthetic and it is a penicillin allergen. It is categorized under semisynthetic ampicillin derived acyl ureido penicillin.
The procurement of Azlocillin is influenced by its application in the pharmaceutical and medical industries as an antibiotic used against various bacterial strains. The rising cases of bacterial infections are increasing the demand for Azlocillin. Azlocillin is highly effective against Pseudomonas aeruginosa, including many strains resistant to other antibiotics like carbenicillin and ticarcillin, driving its demand in treating challenging infections.
Unlike many other penicillins, Azlocillin maintains strong potency against a wide range of bacteria, including Gram-positive organisms, fastidious Gram-negative organisms, and many obligate anaerobes, making it a versatile choice in clinical settings. Its ability to target multi-resistant bacterial strains enhances its use in treating complex infections, supporting its market growth. Rising healthcare awareness and better healthcare facilities for people all over the globe further amplifies its demand.
Ongoing research and development efforts aimed at enhancing the efficacy and delivery methods of Azlocillin are driving its market growth. Innovations in formulation and administration improve patient adherence. Overall, industrial Azlocillin procurement is influenced by its application in the pharmaceutical and medical industries as an antibiotic, rising cases of bacterial infections, high efficacy, strong potency, broad-spectrum, increasing healthcare awareness and facilities, its ability to treat complex infections, and regulatory approvals.
Raw Material for Azlocillin Production
According to the Azlocillin production plant project report, the key raw material used in the production of Azlocillin includes 2-Imidazolidinone.
Production Process of Azlocillin
The extensive Azlocillin production cost report consists of the following major industrial production process:
- Production from 2-Imidazolidinone: The production process of Azlocillin starts with the acylation of 2-Imidazolidone with phosgene to give 1-chlorocarbonyl-2-imidazolidinone, which is further treated with reacted d(–)-α-phenylglycine to form N -(2-oxoimidazolidin-1-carboxamido)-phenylglycine. Finally, the compound is reacted with 6-APA in the presence of triethylamine to produce Azlocillin.
Azlocillin appears as a white to off-white crystalline powder having the molecular formula C20H23N5O6S and a molecular weight of 461.5 g/mol. It is soluble in water in the form of sodium salt, having a solubility of around 50 mg/ml. It has an estimated water solubility of 0.233 mg/mL. It is also soluble in various organic solvents. It has a log P value of 0.2. The value of its dissociation constant, pKa, is 3.49. It has a melting point in the range of 163-167°C. It is a semisynthetic derivative, a penicillin allergen, and the conjugate acid of an azlocillin. It is an antibiotic used to treat infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae.