The report provides a detailed analysis essential for establishing an Aztreonam production plant. It encompasses all critical aspects necessary for Aztreonam production, including the cost of Aztreonam production, Aztreonam plant cost, Aztreonam production costs, and the overall Aztreonam production plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Aztreonam production plant. These encompass production processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.
Aztreonam is a broadly prescribed antibiotic used to treat infections such as septicemia, lower respiratory tract infections, gynecologic infections, skin and skin structure infections, urinary tract infections, and intra-abdominal infections caused by certain types of gram-negative bacteria. This drug belongs to the beta-lactam family. The first discovery was made from a Chromobacterium violaceum bacterium. It works by attaching itself to penicillin-binding proteins, which prevents the formation of cell walls and slows down bacterial growth.
The procurement of Aztreonam is influenced by its use in pharmaceutical and medical industries as an antibiotic to treat various bacterial infections. The rising cases of bacterial infections is increasing the demand for Aztreonam. It is not affected by beta-lactamase, the enzyme that destroys many other antibiotics, which therefore allows it to target certain types of bacteria, especially those causing infection in the meninges, bladder and kidneys hence increasing its market attractiveness.
The general availability of generic versions of Aztreonam has also increased the size of its market by giving choices, thereby reaching out to a greater population of patients and healthcare providers. Furthermore, Aztreonam remains popular since it is available both for injection and inhalation allowing physicians make a choice on how to handle definite infections, thus promoting its market appeal. Overall, industrial Aztreonam procurement is influenced by its utilization in the pharmaceutical and medical industries as an antibiotic, rising cases of bacterial infections, resistance to beta-lactamase, availability in generic versions and various dosage forms, and regulatory approvals.
Raw Material for Aztreonam Production
According to the Aztreonam production plant project report, the key raw material used in the production of Aztreonam includes (tert-butoxycarbonyl)-l-Allothreonine.
Manufacturing Process of Aztreonam
The extensive Aztreonam production cost report consists of the following major industrial production process:
- Production from (tert-butoxycarbonyl)-l-Allothreonine: The production process of Aztreonam starts with the reaction of the starting compound with O-benzylhydroxylamine in the presence of HOBt (1-hydroxybenzotriazole) and DCCI (dicyclohexylcarbodiimide) in THF to form an amide. The amide undergoes cyclization in the presence of PPh3 and diethyl azodiformate in THF to give β-lactam. The compound is subjected to reduction by H2 catalyzed by Pd/C in ethanol to form an intermediate. The intermediate undergoes reduction in the presence of TiCl3 in methanol to give another intermediate. The intermediate is subjected to hydrolysis and is reacted with benzyl chloroformate to give the third intermediate. The intermediate undergoes sulfonation with SO3 in DMF, and further treatment of the resulting product with tetrabutylammonium sulfate in DCM gives the sulfonic acid tetrabutylammonium salt. The compound undergoes debenzylation with H2 catalyzed by Pd/C in DMF to form an intermediate. The intermediate is subjected to condensation with the acetic acid in acetone to give the final intermediate. Finally, the intermediate undergoes hydrolyzation with trifluoroacetic acid to produce Aztreonam.
Aztreonam, commercially known as Azactam, is a white to pale yellow crystalline powder having the molecular formula C13H17N5O8S2 and a molecular weight of 435.4 g/mol. It is almost insoluble in water, with an estimated water solubility of 0.0429 mg/mL. It has a log P value of 0.04. The value of its dissociation constant, pKa, is 3.91. It is a monocyclic beta-lactam antibiotic used to treat various bacterial infections.