Balsalazide Production Cost Reports

The report provides a detailed analysis essential for establishing a Balsalazide manufacturing plant. It encompasses all critical aspects necessary for Balsalazide production, including the cost of Balsalazide production, Balsalazide plant cost, Balsalazide production costs, and the overall Balsalazide manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Balsalazide production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Balsalazide is a medication administered to treat ulcerative colitis which is a condition that causes inflammation of the colon or the large intestine. As this medication has the ability to reduce colon inflammation, it can also be used to control bleeding, diarrhea, and stomachache. In order to guarantee long-term symptom management, it is also used as a long-term maintenance medication to stop ulcerative colitis from relapsing. It is an anti-inflammatory medication also used to treat inflammatory bowel disease (IBD).

The procurement of Balsalazide is influenced by its application in the pharmaceutical and medical industries as an anti-inflammatory medication used to treat ulcerative colitis and IBD. The rising cases of ulcerative colitis and IBD are increasing the demand for Balsalazide. Balsalazide has shown effectiveness in treating mild-to-moderate ulcerative colitis, proving to be as effective or even more effective than mesalazine and sulfasalazine in well-designed clinical trials, driving its demand in the market.

Balsalazide’s market expansion is supported by the fact that patients prefer it over mesalazine because of its quicker onset of action, which helps relieve ulcerative colitis symptoms more quickly. The drug’s ability to prevent relapse in ulcerative colitis patients over long-term treatment periods also enhances its market appeal for both acute and maintenance therapy.

It is better tolerated by patients compared to standard sulfasalazine formulations, making it a favorable option for those requiring long-term treatment, thus driving market expansion. Overall, industrial Balsalazide procurement is influenced by its application in the pharmaceutical and medical industries as an anti-inflammatory, rising cases of ulcerative colitis and IBD, greater efficacy, quick onset of action, long-term usage, better tolerability, and regulatory approvals.

Raw Material for Balsalazide Production

According to the Balsalazide manufacturing plant project report, the key raw material used in the production of Balsalazide includes 4-nitrobenzoyl chloride.

Manufacturing Process of Balsalazide

The extensive Balsalazide production cost report consists of the following major industrial manufacturing process:

• Production from 4-nitrobenzoyl chloride: The manufacturing process of Balsalazide starts with the acylation of 4-nitrobenzoyl chloride with β-Alanine in aqueous alkaline solution to form N-(4-nitrobenzoyl)-b-alanine. The compound undergoes hydrogenolysis with Pd/C in methanol to give N-(4-aminobenzoyl)-b-alanine. The resulting compound is subjected to diazotization with sodium nitrite in aqueous hydrochloric acid to form the diazonium salt. Finally, the salt is coupled with salicylic acid in an alkaline medium to produce Balsalazide.

Balsalazide, commercially known as Colazal, is a yellow to orange crystalline powder having the molecular formula C17H15N3O6 and a molecular weight of 357.32 g/mol. It is freely soluble in water as disodium salt. It has an estimated water solubility of 0.0621 mg/mL. It is also soluble in dimethyl sulfoxide (DMSO) and methanol. It has a log P value of 3.37. The value of its dissociation constant, pKa, is 3.06. It is an anti-inflammatory medication used to treat ulcerative colitis and inflammatory bowel disease.