Besifloxacin Hydrochloride Production Cost Reports

The report provides a detailed analysis essential for establishing a Besifloxacin Hydrochloride manufacturing plant. It encompasses all critical aspects necessary for Besifloxacin Hydrochloride production, including the cost of Besifloxacin Hydrochloride production, Besifloxacin Hydrochloride plant cost, Besifloxacin Hydrochloride production costs, and the overall Besifloxacin Hydrochloride manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Besifloxacin Hydrochloride production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Besifloxacin Hydrochloride is a synthetic ophthalmic antibiotic belonging to the fourth generation of fluoroquinolone antibiotics used for the treatment of bacterial conjunctivitis. It is a broad-spectrum antibiotic that targets, binds to, and inhibits bacterial topoisomerase IV as well as bacterial DNA gyrase, thus inhibiting bacterial cell division, transcription, DNA replication, and DNA repair.

The procurement of Besifloxacin Hydrochloride is influenced by its application in the pharmaceutical and medical industries as an antibiotic used to treat bacterial conjunctivitis. It has shown robust in vitro action against a variety of anaerobic, Gram-positive, and Gram-negative pathogens, thus increasing its demand. The demand for Besifloxacin Hydrochloride is also increasing due to the rising cases of bacterial eye infections, mainly conjunctivitis.

Besifloxacin has been shown in clinical trials to be safe and effective in treating acute bacterial conjunctivitis in both adults and children. The trials also showed a low incidence of adverse events and high rates of bacterial eradication and clinical resolution. It has also been effective in treating acute bacterial keratitis. Besifloxacin may be superior to other fluoroquinolones of the present generation in terms of antibacterial prophylaxis for ocular surgery.

In general, the industrial Besifloxacin Hydrochloride procurement is influenced by its application in the pharmaceutical and medical industries as an antibiotic, the rising cases of eye infections, fewer side effects, its wide range of applications, along with cost-effectiveness, research and development, patient compliance, and regulatory approvals.

Raw Material for Besifloxacin Hydrochloride Production

According to the Besifloxacin Hydrochloride manufacturing plant project report, the key raw material used in the production of Besifloxacin Hydrochloride includes ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate.

Manufacturing Process of Besifloxacin Hydrochloride

The extensive Besifloxacin Hydrochloride production cost report consists of the following major industrial manufacturing process:

• Production from ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate: The manufacturing process of Besifloxacin Hydrochloride involves several key steps. In the first step, ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate undergoes a condensation reaction with triethyl orthoformate to form a mixture of vinylogous esters. The ester is then converted to vinylogous amide by substitution with cyclopropanamine as an undetected mixture of cis- and trans-isomers. This mixture is then treated with a base at elevated temperature to give another intermediate. This intermediate is then subjected to nucleophilic substitution by Iminoazepine, and the displacement reaction proceeds regioselectively to form the atomic structure of Besifloxacin. Finally, the compound undergoes methanolysis at a high temperature to produce Besifloxacin Hydrochloride.

Besifloxacin Hydrochloride is the hydrochloride salt of Besifloxacin. It is commercially known as Besivance. It appears as a white to light brown powder, having the molecular formula C19H22Cl2FN3O3 and a molecular weight of 430.3 g/mol. It has a water solubility of 0.143 mg/mL. It is insoluble in ethanol and DMSO. The value of its log P is 0.7. It is a synthetic antibiotic belonging to the fourth generation of fluoroquinolone antibiotics used for the treatment of bacterial conjunctivitis.