Bicalutamide Production Cost Reports

The report provides a detailed analysis essential for establishing a Bicalutamide manufacturing plant. It encompasses all critical aspects necessary for Bicalutamide production, including the cost of Bicalutamide production, Bicalutamide plant cost, Bicalutamide production costs, and the overall Bicalutamide manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Bicalutamide production plant.

These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Bicalutamide is a medication used in combination with hormone therapy to treat advanced prostate cancer that has spread to other parts of the body. It functions by preventing male hormones from acting in a way that could enhance the formation of cancer cells in the prostate.

This combination of treatments aids in managing symptoms and slowing the cancer's progression. As a pure, non-steroidal anti-androgen with an affinity for androgen receptors, Bicalutamide blocks the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue.

The procurement of Bicalutamide is influenced by its application in the pharmaceutical and medical industries as an anticancer medication used to treat prostate cancer. As prostate cancer becomes more frequent, especially among the elderly population, its treatment by drugs such as Bicalutamide is in high demand. The effectiveness of Bicalutamide, when administered together with LHRH agonists, establishes it as a standard treatment of metastatic prostate cancer, hence driving the market.

The relatively acceptable side effect profile of Bicalutamide in comparison with other treatments is a great boon to its use and thus contributes to its market growth. Increased awareness and early diagnosis of prostate cancer are leading to higher treatment rates, boosting the demand for Bicalutamide. Overall, industrial Bicalutamide procurement is influenced by its application in the pharmaceutical and medical industries as an anticancer mediation, rising cases of prostate cancer, the aging population, combination therapy, fewer side effects, better tolerability, and regulatory approvals.

Raw Material for Bicalutamide Production

According to the Bicalutamide manufacturing plant project report, the key raw material used in the production of Bicalutamide includes 3-trifluoromethyl4-cyanoaniline.

Manufacturing Process of Bicalutamide

The extensive Bicalutamide production cost report consists of the following major industrial manufacturing process:

• Production from 3-trifluoromethyl4-cyanoaniline: The manufacturing process of Bicalutamide starts with the reaction of the starting compound with methacryloyl chloride to form N-(3-trifluoromethyl-4-cyanophenyl)methacrylamide. The resultant compound is subjected to epoxidation to give an epoxide intermediate. The epoxide is opened opened with 4-fluorothiophenol to form the thioether intermediate, which is further converted to sulfone to produce Bicalutamide.

Bicalutamide, commercially known as Casodex, is a white to off-white crystalline powder having the molecular formula C18H14F4N2O4S and a molecular weight of 430.4 g/mol. It has a melting point in the range of 191-193 °C. It is almost insoluble in water with a solubility of 5mg/L at 37 °C. It easily dissolves in acetone and tetrahydrofuran. It dissolves to some extent in chloroform and ethanol and is sparingly soluble in methanol. It has a log P value of around 2.5. The value of its dissociation constant, pKa, is 12.0. It is known as an oral, non-steroidal anti-androgen used to treat prostate cancer. It is made up of a racemic combination in which the (R)- and (S)-bicalutamide enantiomers are split 50:50.