Bilastine Production Cost Reports

The report provides a detailed analysis essential for establishing a Bilastine manufacturing plant. It encompasses all critical aspects necessary for Bilastine production, including the cost of Bilastine production, Bilastine plant cost, Bilastine production costs, and the overall Bilastine manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Bilastine production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Bilastine is a medication that belongs to a class of drugs called antihistamines. It is used for the management of chronic spontaneous urticaria and allergic rhinitis of seasonal patterns. It operates by blocking the body’s ability to produce histamine, which is produced during an allergic reaction. Bilastine reduces the signs of allergic rhinitis and urticaria by blocking histamine receptors.

The procurement of Bilastine is influenced by its application in the pharmaceutical and medical industries as an antihistaminic used to treat chronic spontaneous urticaria and allergic rhinitis. The widespread occurrence of allergic conditions such as seasonal rhinitis and spontaneous chronic urticaria is significantly increasing the demand for Bilastine.

It has been demonstrated to exhibit considerable effectiveness in diminishing symptoms associated with allergies while concurrently upholding a satisfactory safety profile. Due to a comparatively reduced incidence of adverse effects relative to alternative antihistamine options, the preference for it among individuals is notably heightened, thereby increasing its demand.

The enhancement of patient adherence and convenience arises from the introduction of innovative formulations, including the oral dispersible tablet (ODT), which notably extends the demographic of potential beneficiaries, particularly aiding pediatric populations and individuals experiencing difficulties in the act of swallowing solid dosage forms, thus amplifying its market presence.

Moreover, the availability of Bilastine as an over-the-counter option in selected geographical regions further broadens the accessibility for individuals seeking non-prescription remedies for allergy-related symptoms, consequently leading to an expansion of market growth. Overall, industrial Bilastine procurement is influenced by its application in the pharmaceutical and medical industries, rising cases of allergic conditions, high efficacy, fewer side effects, patient compliance, novel formulations, OTC availability, and regulatory approvals.

Raw Material for Bilastine Production

According to the Bilastine manufacturing plant project report, the key raw material used in the production of Bilastine includes o-phenylene diamine.

Manufacturing Process of Bilastine

The extensive Bilastine production cost report consists of the following major industrial manufacturing process:

• Production from o-phenylene diamine: The manufacturing process of Bilastine starts with the reaction of o-phenylene diamine with Tosyl-diethyl ester in the presence of NaOH and DMSO to form (N1-(2-ethoxyethyl) benzene-1,2-diamine). The compound reacts with 1-piperidine-4-carboxylic acid to give an intermediate. The intermediate is treated in the presence of a base like sodium bicarbonate to form the final intermediate. Finally, the compound is purified in the presence of n-butanol to produce Bilastine.

Bilastine, commercially known as Blexten, is a white to light-yellow crystalline powder having the molecular formula C28H37N3O3 and a molecular weight of 463.6 g/mol. It has an estimated water solubility of 0.00203 mg/mL. It has a log P value of 5.02. The value of its dissociation constant, pKa, is 4.06. It has a melting point in the range of 199.0 to 203.0°C. It is a brand-new, next-generation antihistamine with a quick onset and a long half-life. It is extremely selective for the H1 histamine receptor. It is used to treat several allergic conditions, such as seasonal rhinitis and spontaneous chronic urticaria.