Boloxavir Marboxil Production Cost Reports

The report provides a detailed analysis essential for establishing a Boloxavir Marboxil manufacturing plant. It encompasses all critical aspects necessary for Boloxavir Marboxil production, including the cost of Boloxavir Marboxil production, Boloxavir Marboxil plant cost, Boloxavir Marboxil production costs, and the overall Boloxavir Marboxil manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Boloxavir Marboxil production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Boloxavir Marboxil is an FDA-approved antiviral drug that finds huge applications in the pharmaceutical industry. It is widely used as a drug for the treatment of various types of influenza infections (flu) in adults and children aged 5 years and above. Additionally, the compound is often utilized in alleviating the symptoms associated with flu virus infections in patients who show symptoms of this infection for not more than 48 hours. It is also used to manage and reduce the impact of influenza outbreaks.

The market for Boloxavir Marboxil is majorly driven by its usage as an oral drug that is extremely effective against flu virus infection, which remarkably boosts its demand in the pharmaceutical and healthcare industries. Moreover, its application for the treatment of acute uncomplicated influenza infection further contributes to its increase in demand and fuels its market expansion. Additionally, procurement practices are defined on the basis of several factors, including the cost and the availability of raw materials (fluoro-benzothiaphene, etc.), its medical applications, and regulatory compliance. Moreover, technological advancements related to its applications, supplier reliability, sustainability practices, and efficient logistics largely impact industrial Boloxavir Marboxil procurement globally.

Raw Material for Boloxavir Marboxil Production

According to the Boloxavir Marboxil manufacturing plant project report, the major raw materials for Boloxavir Marboxil production include Quinoline-3-Carboxylate Derivative- Fluoro-Benzothiophene Derivative and 1-Propanephosphonic Anhydride (T3P) and Methanesulfonic Acid.

Manufacturing Process of Boloxavir Marboxil

The extensive Boloxavir Marboxil production cost report consists of the following industrial manufacturing process:

1. Production via Coupling Reaction: This method of production involves the coupling of 1-R (Quinoline-3-carboxylate derivative) and 2-fragments (Fluoro-benzothiophene derivative) in the presence of 1-propanephosphonic anhydride (T3P) and methanesulfonic acid as dehydrating agents at 70°C, which results in the formation of protected baloxavir. Then, the obtained baloxavir is further reacted with PhBr and K2CO3 (0.6 equivalents), followed by the process of debenzylation by using LiCl in N,N-dimethylacetamide (CH3CONMe2) to obtain baloxavir acid (94%). As the final step, baloxavir acid is reacted with chloromethyl methyl carbonate in the presence of dimethylacetamide, which leads to formation of baloxavir marboxyl (BXM)as the final product.

Boloxavir Marboxil is a prodrug with antiviral activity. The molar mass of the compound is 571.6 g/mol, and its molecular formula is C27H23F2N3O7S. The compound is mainly marketed under the brand name Xofluza. Moreover, the boiling point of the compound is 712.8°C, and its density is 1.57 g/cm3. The compound appears in the form of a crystalline solid that is stored in the freezer sealed in a container at a temperature of -20°C. It serves as a medication that is widely available in the form of a single dose oral tablet. Additionally, the compound does not dissolve in water but is soluble in DMSO at 45mg/mL, and its dissociation constant (pka) value is -1.46.