Brimonidine Production Cost Reports

The report provides a detailed analysis essential for establishing a Brimonidine manufacturing plant. It encompasses all critical aspects necessary for Brimonidine production, including the cost of Brimonidine production, Brimonidine plant cost, Brimonidine production costs, and the overall Brimonidine manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Brimonidine production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Brimonidine is a medication used to lower high pressure in the eye for people with conditions like open-angle glaucoma or ocular hypertension. It can be used alone or with another medicine called brinzolamide. It is also utilized as a topical treatment for skin conditions to reduce persistent facial redness caused by rosacea in adults aged 18 years and older. The medicine is applied directly to the skin to help manage this long-term condition. It is a member of the class of drugs called alpha-2 adrenergic agonists.

The procurement of Brimonidine is influenced by its application in the pharmaceutical and medical industries as an alpha-2 adrenergic agonist to treat glaucoma and ocular hypertension. The rising cases of glaucoma and ocular hypertension are increasing the demand for Brimonidine. Its effectiveness in significantly lowering intraocular pressure, either alone or in combination with other drugs, enhances its adoption in managing eye conditions, supporting market growth.

It has also been approved for treating persistent facial redness in rosacea patients which broadens its application, contributing to market growth beyond ophthalmology. New generation of Brimonidine preparations available includes extended-release implant forms and new biodegradable systems, which boost patient adherence.

These preparations have shown some advantages that help in reducing side effects besides enhancing the patient’s outcome which amplifies its market presence. Overall, industrial Brimonidine procurement is influenced by its application in the pharmaceutical and medical industries as an alpha-2 adrenergic agonist, rising cases of glaucoma and ocular hypertension, higher efficacy, combination therapy, and regulatory approvals.

Raw Material for Brimonidine Production

According to the Brimonidine manufacturing plant project report, the key raw material used in the production of Brimonidine includes 6-amino-5- bromoquinoxaline.

Manufacturing Process of Brimonidine

The extensive Brimonidine production cost report consists of the following major industrial manufacturing process:

• Production from 6-amino-5- bromoquinoxaline: The manufacturing process of Brimonidine starts with the reaction of 6-amino-5- bromoquinoxaline with N- acetyl ethylene urea in the presence of phosphorus oxychloride to form acetyl brimonidine. Finally, the acetyl brimonidine obtained undergoes hydrolyzation with methanolic sodium hydroxide to produce Brimonidine.

Brimonidine, commercially known as Alphagan, is a white to off-white crystalline powder having the molecular formula C11H10BrN5 and a molecular weight of 292.13 g/mol. It has a melting point of around 207.5°C. It is soluble to some extent in water and soluble in methanol and ethanol. It has a water solubility of 34 mg/mL. It has a log P value of around 1.7. The value of its dissociation constant, pKa, is 7.78. Brimonidine is a secondary amine, a derivative of quinoxaline, and an imidazole. It functions as an alpha-adrenergic agonist, an adrenergic agonist, and an antihypertensive.