Cefditoren Pivoxil Production Cost Reports

The report provides a detailed analysis essential for establishing a Cefditoren Pivoxil manufacturing plant. It encompasses all critical aspects necessary for Cefditoren Pivoxil production, including the cost of Cefditoren Pivoxil production, Cefditoren Pivoxil plant cost, Cefditoren Pivoxil production costs, and the overall Cefditoren Pivoxil manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Cefditoren Pivoxil production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Cefditoren Pivoxil is an antibiotic used to treat bacterial infections. It is a third-generation cephalosporin antibiotic that is semi-synthetic, broad-spectrum, resistant to beta-lactamases, and has bactericidal activity. It is used to treat infections such as acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia pharyngitis and tonsillitis, acute maxillary sinusitis, otitis media, and skin and skin structure infections.

The procurement of Cefditoren Pivoxil is influenced by its application in the pharmaceutical and medical industries as an antibiotic used to treat various bacterial infections. The rising cases of bacterial infections are increasing the demand for Cefditoren Pivoxil. Its dual action against both Gram-positive and Gram-negative bacteria, including prevalent respiratory and skin pathogens, drives its demand for use in a wide variety of infections.

Its efficacy against penicillin-susceptible and -intermediate Streptococcus pneumoniae, S. pyogenes, as well as methicillin-susceptible Staphylococcus aureus, places it formally as one of the key antibiotics in the treatment of resistant bacterial infections. Because of its broad-spectrum activity, Cefditoren Pivoxil has been made an alternative drug for different kinds of infections, thereby amplifying its market presence. Overall, industrial Cefditoren Pivoxil procurement is influenced by its application in the pharmaceutical and medical industries as an antibiotic, rising cases of bacterial infections, higher efficacy, broad-spectrum, and regulatory approvals.

Raw Material for Cefditoren Pivoxil Production

According to the Cefditoren Pivoxil manufacturing plant project report, the key raw material used in the production of Cefditoren Pivoxil includes p-Methoxybenzyl-7-phenylacetamido-3-chloromethyl-3-cephem-4-carboxylate.

Manufacturing Process of Cefditoren Pivoxil

The extensive Cefditoren Pivoxil production cost report consists of the following major industrial manufacturing process:

1. Production from p-Methoxybenzyl-7-phenylacetamido-3-chloromethyl-3-cephem-4-carboxylate: The manufacturing process of Cefditoren Pivoxil starts with the treatment of the starting compound with NaI in acetone to form the corresponding iodide. The iodide is further treated with PPh3 to yield the triphenylphosphonium iodide. The compound undergoes Wittig reaction with 5-formyl-4-methylthiazole in DCM/H2O at room temperature in the presence of sodium bicarbonate to give the vinyl derivative. The 7-N-phenylacetyl substituent of the vinyl derivative is removed by standard method (PC15 and then MeOH) to give 7-aminocephem ester, which is further coupled with 2-(2-tritylaminothiazol-4-yl)-2(Z)-methoxyiminoacetic acid using POC13 to form the protected derivative. The derivative is deprotected with trifluoroacetic acid in anisole to give Cefditoren. Finally, Cefditoren is esterified with iodomethyl pivalate to produce Cefditoren Pivoxil.

Cefditoren Pivoxil, commercially known as Spectracef, is a white-to-yellow crystalline powder having the molecular formula C25H28N6O7S3 and a molecular weight of 620.7 g/mol. It has an estimated water solubility of 0.0134 mg/mL. It has a log P value of 2.9. The value of its dissociation constant, pKa, is 10.82. It has a melting point in the range of 194-196°C. It is soluble in methanol and ethanol. It is a third-generation cephalosporin antibiotic used to treat various bacterial infections.