Cefoxitin Production Cost Reports

The report provides a detailed analysis essential for establishing a Cefoxitin manufacturing plant. It encompasses all critical aspects necessary for Cefoxitin production, including the cost of Cefoxitin production, Cefoxitin plant cost, Cefoxitin production costs, and the overall Cefoxitin manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Cefoxitin production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Cefoxitin is an antibiotic used to treat severe bacterial infections. It helps the body get rid of certain kinds of bacteria that are known to cause these infections and enhances health by doing so. It is a member of broad-spectrum cephamycin antibiotics used for the treatment of severe bacterial infections, including blood infections, urinary tract infections, bone and joint infections, and lower respiratory tract infections. Its bactericidal activity derives from its inhibition of cell wall formation.

The procurement of Cefoxitin is influenced by its utilization in the pharmaceutical and medical industries as an antibiotic used to treat severe bacterial infections. The widespread occurrence of bacterial infections is significantly increasing the demand for Cefoxitin. The generic versions of the medication have improved pricing and accessibility, which has increased usage in a variety of healthcare settings, thereby contributing to its demand.

The need for preventive antibiotics like Cefoxitin to prevent post-operative infections supports its market expansion. Overall, industrial Cefoxitin procurement is influenced by its utilization in the pharmaceutical and medical industries as an antibiotic, the rising cases of bacterial infections, generic versions, increasing healthcare awareness, preventive role in post-operative infections, and regulatory approvals.

Raw Material for Cefoxitin Production

According to the Cefoxitin manufacturing plant project report, the key raw material used in the production of Cefoxitin includes 7-aminocephalosporanic acid.

Manufacturing Process of Cefoxitin

The extensive Cefoxitin production cost report consists of the following major industrial manufacturing process:

• Production from 7-aminocephalosporanic acid: The manufacturing process of Cefoxitin starts with the tosylation of the amino group of the starting compound to form its benzhydryl ester. The ester is reacted with nitrous acid to give diphenyl methyl ester of 7-diazocephalosporanic acid. The compound is reacted with triethylammonium azide in dichloromethane to form diphenyl methyl ester of 7-bromo-7-azidocephalosporanic acid. The compound is reacted with methanol in the presence of silver borofluoride to form an intermediate. The intermediate undergoes reduction by using hydrogen in the presence of a platinum oxide catalyst to form another intermediate. The intermediate is subjected to acylation with 2-(2-thienyl)acetylchloride to give the third intermediate. The ester-protecting group of the intermediate undergoes hydrolysis by using trifluoroacetic acid and then reacts with sodium bicarbonate and is converted to the potassium salt. The compound undergoes hydrolysis to form the final intermediate. Finally, the intermediate is treated with chlorosulfonyl isocyanate, followed by hydrolysis with water to produce Cefoxitin.

Cefoxitin, commercially known as Mefoxin, appears as a white to off-white crystalline powder having the molecular formula C16H17N3O7S2 and a molecular weight of 427.5 g/mol. It has a melting point in the range of 165-167 °C. It has a water solubility of around 0.195 mg/mL. The value of its dissociation constant, pKa, is 3.39. It dissolves easily in acetone. It is soluble in aqueous sodium bicarbonate. However, it is insoluble in ether and chloroform. It is a broad-spectrum antibiotic used for the treatment of various bacterial infections.