Cevimeline Hydrochloride Production Cost Reports

The report provides a detailed analysis essential for establishing a Cevimeline Hydrochloride manufacturing plant. It encompasses all critical aspects necessary for Cevimeline Hydrochloride production, including the cost of Cevimeline Hydrochloride production, Cevimeline Hydrochloride plant cost, Cevimeline Hydrochloride production costs, and the overall Cevimeline Hydrochloride manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Cevimeline Hydrochloride production plant.

These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Cevimeline Hydrochloride is a medicinal product that is used by patients who develop dry mouth because of Sjogren’s syndrome. This syndrome is immunologically related, and it may cause dryness in the mouth and other parts of the body. It acts through activating some specific receptors of the body which is similar to the natural element known as acetylcholine. This stimulation assists in the production of saliva, and therefore, lets the patient be comfortable eating, drinking, and even speaking.

The procurement of Cevimeline Hydrochloride is influenced by its application in the pharmaceutical and medical industries to treat symptoms associated with Sjogren’s syndrome. The widespread occurrence of Sjogren’s syndrome is significantly increasing the demand for Cevimeline Hydrochloride. It has been demonstrated that Cevimeline Hydrochloride works well to reduce the xerostomia (dry mouth) symptoms linked to Sjogren’s syndrome.

Its predominance as a therapy option is increased by clinical trials showing notable improvements in patient-reported outcomes, which amplifies its market appeal. Research into additional therapeutic uses of Cevimeline Hydrochloride, such as its effects on other exocrine gland dysfunctions or its role in managing certain neurological conditions, contributes to its market demand.

Patients find Cevimeline Hydrochloride more accessible and reasonably priced due to the availability of generic versions. Adoption rates may rise because of this improved accessibility, especially in areas with scarce healthcare resources, which increases the demand. Overall, industrial Cevimeline Hydrochloride procurement is influenced by its application in the pharmaceutical and medical industries, rising cases of Sjogren’s syndrome, high efficacy, additional therapeutic usage, availability of generic versions, and regulatory approvals.

Raw Material for Cevimeline Hydrochloride Production

According to the Cevimeline Hydrochloride manufacturing plant project report, the key raw material used in the production of Cevimeline Hydrochloride includes quinuclidin-3-one.

Manufacturing Process of Cevimeline Hydrochloride

The extensive Cevimeline Hydrochloride production cost report consists of the following major industrial manufacturing process:

• Production from quinuclidin-3-one: The manufacturing process of Cevimeline Hydrochloride starts with the epoxidation of quinuclidine-3-one with Trimethyl Sulfoxonium Iodide in the presence of DMSO and NaH (Corey-Chaykovsky conditions) to form the epoxide. The epoxide is reacted with hydrogen sulfide to give the thiol. The thiol undergoes cyclization with acetaldehyde in the presence of BF3.Et2O to form an intermediate. Finally, the intermediate is purified to produce Cevimeline Hydrochloride.

Cevimeline Hydrochloride, commercially known as Evoxac, is a white to light-yellow crystalline powder having the molecular formula C10H18ClNOS and a molecular weight of 235.77 g/mol. It has an estimated water solubility of 2.41 mg/mL. It has a log P value of 1.46. The value of its dissociation constant, pKa, is 8.59. It is a hydrochloride salt of Cevimeline. It is a cholinergic analog used to treat symptoms associated with Sjogren’s syndrome.