Chlorothiazide Production Cost Reports

The report provides a detailed analysis essential for establishing a Chlorothiazide manufacturing plant. It encompasses all critical aspects necessary for Chlorothiazide production, including the cost of Chlorothiazide production, Chlorothiazide plant cost, Chlorothiazide production costs, and the overall Chlorothiazide manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Chlorothiazide production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Chlorothiazide is a diuretic that can be used to treat disorders related to fluid retention and high blood pressure. It works by acting on certain tubules in the kidneys and helps to excrete sodium chloride through the urine, resulting in a reduction of water/fluid retention. This process is useful in managing problems related to edema and hypertension. It manages excess fluid when the heart is not pumping effectively during Congestive Heart Failure. It is useful in liver diseases like of cirrhosis to control fluid that collects in the abdomen. Chlorothiazide is utilized in nephrotic syndrome and acute glomerulonephritis treatment. It is popular in treating hormonal disorders that arise from corticosteroid or estrogen therapy. It is used as an antihypertensive agent in combination with other medications to lower blood pressure and reduce the risk of heart attack and stroke.

Chlorothiazide market is driven by its effectiveness in treating fluid retention and hypertension. Its benefits in patients with congestive heart failure surge its demand. Its growing demand for managing edema associated with liver cirrhosis and kidney diseases like nephrotic syndrome and acute glomerulonephritis further contributes to its growing demand in clinical practice.

Chlorothiazide application in hormonal disorders resulting from corticosteroid and estrogen therapies has led to a significant increase in demand. It is prescribed as an antihypertensive agent to reduce the risk of heart attack and stroke, which drives its demand among healthcare providers. The changes in its demand as a diuretic medication for multiple medical applications, along with its production prices, market prices, and logistics, directly influence industrial Chlorothiazide procurement in the market across the globe.

Raw Material for Chlorothiazide Production

According to the Chlorothiazide manufacturing plant project report, the key raw materials used in the production of Chlorothiazide include 5-chloro-2,4-disulfamylanilin-Formic Acid-Solvents.

Manufacturing Process of Chlorothiazide

The extensive Chlorothiazide production cost report consists of the following major industrial manufacturing processes:

• From 5-chloro-2,4-disulfamylanilin, Formic Acid and Solvents: The industrial manufacturing of Chlorothiazide consists of several steps. First, 5-chloro-2,4-disulfamylaniline is cyclized using formic acid with heating at 90-100 °C. This cyclization reaction introduces the thiazide ring structure that is present in Chlorothiazide. The crude product is purified by using solvent and cooled to obtain pure Chlorothiazide. The final product is converted into the required formulations.

Chlorothiazide is a white or nearly white crystalline powder. Its IUPAC name is 6-Chloro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide. It has a molecular formula of CHClNOS and a molar mass of 295.71 g/mol. It is soluble in water and dimethylformamide but almost insoluble in ether. It has a melting point of 342.5–343 °C. Its partition coefficient is -0.24, which makes it hydrophilic. It has two pKa values at 6.85 and 9.45 pointing towards its acidic character.  It contains no chiral centres and have a benzothiazine ring structure important for its diuretic activity. These physical and chemical properties contribute to its therapeutic properties.