Cinnarizine Production Cost Reports

The report provides a detailed analysis essential for establishing a Cinnarizine manufacturing plant. It encompasses all critical aspects necessary for Cinnarizine production, including the cost of Cinnarizine production, Cinnarizine plant cost, Cinnarizine production costs, and the overall Cinnarizine manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Cinnarizine production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Cinnarizine (Stugeron) is an FDA-approved drug that finds huge applications in the medical field. It is widely utilized as a drug for the management of vestibular disorders and motion sickness. Moreover, it is often used for the treatment of vertigo/Meniere's disease, nausea, and vomiting. Additionally, it is also employed as an anti-histaminic drug for the treatment of some allergic diseases, such as chronic urticaria and senile skin pruritus.

The demand for Cinnarizine is predominantly driven by its application as an oral drug used for the treatment of motion sickness and vertigo, which significantly boosts its demand in the pharmaceutical industry. Moreover, its employment as an antiemetic and a histamine antagonist further accelerates its market expansion. Additionally, its employment as an anti-allergic agent in the treatment of various allergies effectively promotes its demand in the medical and pharmaceutical industries. Furthermore, several factors influence industrial Cinnarizine procurement, including the availability of raw materials (cinnamoyl chloride, etc.), cost and pricing, compliance with pharmaceutical regulations, quality standards, technological advancements, sustainability practices, distribution (including trading and shipping), logistics, safety standards, etc.

Raw Material for Cinnarizine Production

According to the Cinnarizine manufacturing plant project report, the major raw materials for Cinnarizine production include Cinnamoyl Chloride-Benzhydryl Piperazine-Dry Benzene-Toluene-Heptane-Potassium Carbonate.

Manufacturing Process of Cinnarizine

The extensive Cinnarizine production cost report consists of the following industrial manufacturing process:

1. Production via Benzhydryl Piperazine: This method of production is initiated by the reaction of cinnamoyl chloride with benzhydryl piperazine in the presence of dry benzene under reflux. Further, the benzene is evaporated, and the residue is isolated in chloroform, followed by washing with dilute HCL and making it alkaline. Then, the chloroform layer is washed with a dilute aqueous sodium hydroxide solution and with water, followed by drying it over potassium carbonate to form a residue, which is further dissolved in a mixture of 25% of toluene and 75% of heptane by heating. As the last step, the solution is allowed to cool down, followed by reduction with LiAlH4 to obtain cinnarizine as the final product.

Cinnarizine is a derivative of piperazine. The molecular formula of the compound is C26H28N2, and its molecular weight is 368.51 g/mol. Moreover, the compound serves as a drug that is largely marketed under the brand names Stugeron and Dimitron. It is available in the form of oral capsules. Additionally, the melting point of the compound ranges between 117-120°C and its boiling point is 488.83°C. It has a density of 1.1818 g/cm3, and it is stored in a dry place, sealed at -20°C. The compound exists in the form of a white powder with a flash point of 229.8°C. The IUPAC name of the compound is 1-(diphenylmethyl)-4-[(2E)-3-phenyl-2-propen-1-yl]piperazine.