Clemastine Production Cost Reports

The report provides a detailed analysis essential for establishing a Clemastine manufacturing plant. It encompasses all critical aspects necessary for Clemastine production, including the cost of Clemastine production, Clemastine plant cost, Clemastine production costs, and the overall Clemastine manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Clemastine production plant.

These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Clemastine is a member of the class of medication known as first-generation histamine H1 antagonist derived from ethanolamine that is used to treat pruritus, hay fever, rhinitis, and allergic skin disorders.  It is used to reduce allergy-related symptoms like runny nose, watery or itchy eyes, and sneezing, which are frequently linked to allergic rhinitis. It also has sedative and anticholinergic properties. Additionally, it is indicated for the treatment of minor, simple allergic skin symptoms such as angioedema and urticaria. It is also utilized as a self-medication to provide brief alleviation of typical cold symptoms.

The procurement of Clemastine is influenced by its application in the pharmaceutical and medical industries as an antihistaminic medication used to relieve the symptoms associated with allergic rhinitis. The widespread occurrence of allergic rhinitis is significantly increasing the demand for Clemastine. It witnesses a significant boost in demand from the aging population as they are more likely to be affected by allergic problems. Clemastine has shown promising preclinical neuroprotective properties, such as an ability to modulate neuroplasticity, reduce neuroinflammation, and myelinate, which enhances its market appeal.

Clemastine has been shown in recent research to be effective in minimizing brain damage and accelerating recovery after hypoxic-ischemic episodes in animal models, which contributes to its demand. Overall, industrial Clemastine procurement is influenced by its application in the industrial and medical industries, the rising cases of allergic rhinitis and related problems, its neuroprotective properties, research and development, and regulatory approvals.

Raw Material for Clemastine Production

According to the Clemastine manufacturing plant project report, the key raw material used in the production of Clemastine includes 4-chloroactophenone.

Manufacturing Process of Clemastine

The extensive Clemastine production cost report consists of the following major industrial manufacturing process:

• Production from 4-chloroactophenone: The manufacturing process of Clemastine starts with the reaction of 4-chloroactophenone with phenylmagnesium bromide to form 1-(4-chlorophenyl)-1-phenylethanol. Finally, the compound is treated with 2-(2-chlorethyl)-1-methylpyrrolidine using sodium amide as a base to produce Clemastine.

Clemastine, commercially known as Tavegyl, is a white to off-white crystalline powder having the molecular formula C21H26ClNO and a molecular weight of 343.9 g/mol. It has a melting point of around 178 °C. It has an estimated water solubility of 0.000405 mg/mL. It also dissolves in organic solvents like methanol. It has a log P value of 5.2. The value of its dissociation constant, pKa, is 9.55.

It is utilized as an antihistamine with antimuscarinic and mildly sedative qualities to treat allergy disorders like rhinitis, urticaria, conjunctivitis, and severe itching skin conditions. It functions as a muscarinic antagonist, an anti-allergic, an H1-receptor antagonist, and an antipruritic medication. It belongs to the monochlorobenzene family and is an N-alkylpyrrolidine.