Clofazimine Production Cost Reports

The report provides a detailed analysis essential for establishing a Clofazimine manufacturing plant. It encompasses all critical aspects necessary for Clofazimine production, including the cost of Clofazimine production, Clofazimine plant cost, Clofazimine production costs, and the overall Clofazimine manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Clofazimine production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Clofazimine is an antimycobacterial drug that belongs to the class of riminophenazine antibiotics. It is widely used for the treatment and management of the symptoms of lepromatous leprosy. It is used as a drug in combination with other medications, such as rifampicin and dapsone, to prevent drug resistance. It also finds its application in the treatment of multidrug-resistant tuberculosis (MDR-TB).

The market for Clofazimine is primarily driven by its demand as a non-steroidal anti-inflammatory drug for the treatment of leprosy due to its anti-inflammatory effects. Its application as a medication used in combination with other antileprosy agents to treat leprosy and prevent resistance to the drug further enhances also fuels its demand in the medical industry. Its usage as a leprostatic drug for the treatment of leprosy and as a potential treatment for multidrug-resistant tuberculosis also contributes to its demand in the pharmaceutical and healthcare industries.

The patent status and any exclusive marketing rights are important factors that can impact the availability and cost of generic versions of Clofazimine, which further impacts industrial Clofazimine procurement. Clofazimine must meet strict regulatory standards for pharmaceuticals governed by agencies like the FDA. Thus, adherence to these standards largely affects the procurement strategies for Clofazimine. Variations in the supply, cost, and availability of raw materials required for manufacturing Clofazimine further impact its production costs and procurement decisions. Import duties, export controls, and other trade regulations can further influence the cost and supply of pharmaceuticals across borders.

Raw Material for Clofazimine Production

According to the Clofazimine manufacturing plant project report, the major raw materials for Clofazimine production include 2-(p-Chloroanilino)aniline-Iron (III) Chloride-Isopropylamine.

Manufacturing Process of Clofazimine

The extensive Clofazimine production cost report consists of the following industrial manufacturing process:

• Production via Chemical Synthesis: This method of production involves the synthesis of Clofazimine by using 2-(p-chloroanilino)aniline as the starting material. The synthesis begins with the oxidation of 2-(p-chloroanilino)aniline by using a solution of iron (III) chloride in water to produce 2-(p-chloroanilino)-5-(p-chlorophenyl)-3,5-dihydro-3-iminophenazine. Further, the obtained 2-(p-chloroanilino)-5-(p-chlorophenyl)-3,5-dihydro-3-iminophenazine is reacted with isopropylamine, which results in the formation of 2-(p-chloroanilino)-5-(p-chlorophenyl)-3,5-dihydro-3-(iso-propylimino)-phenazine or clofazimine as the final product.

Clofazimine is an antimycobacterial and it exists in the form of an odorless, dark red crystalline solid. The compound belongs to the class of phenazines and monochlorobenzenes. The compound is a fat-soluble riminophenazine dye, which is utilized for the treatment of leprosy. The molecular formula of the compound is C27H22Cl2N4, and its molar mass is around 473.4 g/mol. The melting point of the compound ranges between 210 - 212 °C, and its value of LogP is 7. The compound is not soluble in water and is readily soluble in benzene and chloroform. It is recommended to store the compound protected from heat and moisture.