Clomiphene Production Cost Reports

The report provides a detailed analysis essential for establishing a Clomiphene manufacturing plant. It encompasses all critical aspects necessary for Clomiphene production, including the cost of Clomiphene production, Clomiphene plant cost, Clomiphene production costs, and the overall Clomiphene manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Clomiphene production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Clomiphene, commonly referred to as Clomifene is an FDA approved drug with components of an estrogen agonist and an estrogen antagonist that is commonly used to treat infertility in women. It is useful for women who have a condition of irregular or no menstruation that can be worsened by diseases like PCOS (polycystic ovarian syndrome). It counteracts the actions of estrogen which causes the secretion of more hormones from the brain that in turns stimulates the ovaries to release a fully developed egg. In addition, by increasing the secretion of luteinizing hormone and follicle-stimulating hormone that leads to the increase in testosterone and spermatogenesis, it is also used in the treatment of male infertility.

The market for Clomiphene is driven by its usage as an estrogen receptor modulator for the treatment of infertility in women, which significantly promotes its demand in the pharmaceutical and medical industries. The widespread occurrence of infertility in women is significantly increasing the demand for Clomiphene. Additionally, the rising cases of obesity and PCOS further contribute to its market growth. The drug’s utility extends to off-label uses, such as secondary hypogonadism, performance enhancement for healthy athletes, and primary short-lasting unilateral neuralgiform headache attacks (SUNCT), amplifying its market appeal. Overall, industrial Clomiphene procurement is influenced by its usage in the pharmaceutical and medical industries, rising cases of infertility, PCOS, and obesity, off-label uses, increasing healthcare awareness, and regulatory approvals.

Raw Material for Clomiphene Production

According to the Clomiphene manufacturing plant project report, the key raw material used in the production of Clomiphene includes 4-hydroxybenzophenone.

Manufacturing Process of Clomiphene

The extensive Clomiphene production cost report consists of the following major industrial manufacturing process:

1. Production from 4-hydroxybenzophenone: The manufacturing process of Clomiphene starts with the reaction of 4-hydroxybenzophenone with 2-diethylaminoethylchloride in the presence of an alkali to form 4-(2-diethylaminoethoxy)benzophenone. The resulting compound is treated with benzylmagnesium chloride in a Grignard reaction to give the corresponding carbinol. The carbinol is subjected to dehydration with hydrogen chloride to give 2-[p-(1,2-diphenylvinyl) phenoxy]triethylamine. Finally, the vinylic hydrogen atom of the compound is replaced with a chlorine atom using N-chlorosuccinimide to produce Clomiphene.

Clomiphene, commercially known as Clomid, is a white to pale-yellow powder having the molecular formula C26H28ClNO and a molecular weight of 406.0 g/mol. It has a melting point in the range of 116.5-118 °C. It is slightly soluble in water with an estimated water solubility of 0.000414 mg/mL. It is also soluble in ethanol and chloroform but dissolves better in methanol. Moreover, it is almost insoluble in diethyl ether. It has a log P value of around 7.2. The value of its dissociation constant, pKa, is 9.31. It becomes unstable when exposed to air and light. It is hygroscopic. It is an estrogen receptor modulator (agonist/antagonist depending on the target tissue). It is a triphenyl ethylene stilbene derivative used to treat infertility in women and PCOS.