Clopidogrel Production Cost Reports

The report provides a detailed analysis essential for establishing a Clopidogrel manufacturing plant. It encompasses all critical aspects necessary for Clopidogrel production, including the cost of Clopidogrel production, Clopidogrel plant cost, Clopidogrel production costs, and the overall Clopidogrel manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Clopidogrel production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Clopidogrel stops blood clots formation and can reduce the chances of having a heart attack or stroke. Its mode of action is to block platelet receptors, thereby preventing them from being aggregated. It can benefit those who have non-ST elevation acute coronary syndrome (ACS) or ST-elevation myocardial infarction. For patients who have recently had TIAs, it is a good option for preventing strokes. It helps in the prevention of blood clotting and does vasodilation, thus treating peripheral vascular diseases. Clopidogrel with aspirin helps to manage Acute Coronary Syndromes (ACS) and improve blood flow in the heart vessels following interventional procedures of some coronary surgery.

The Clopidogrel market is mainly driven by increased demand for antiplatelet medication because of the need to prevent heart attacks and strokes. It is used in the treatment of various types of myocardial infarction and may be beneficial for patients who have experienced a transient ischemic attack. It is also used to treat peripheral vascular disease and keep the blood flow. It is used along with aspirin to treat acute coronary syndromes following cardiac procedures and has a large market in post-operative medication. Due to cheap and readily available medicines, it is very useful in healthcare. So, its demand as an antiplatelet medication and its easy accessibility, along with its production prices, market prices, and logistics, directly influence industrial Clopidogrel procurement in the market across the globe.

Raw Material for Clopidogrel Production

According to the Clopidogrel manufacturing plant project report, the key raw materials used in the production of Clopidogrel include 2-chlorobenzyl cyanide- Bromine-( 4,5,6,7-tetrahydrothieno[3,2-c] pyridine hydrochloride)-KOH-Isopropyl Alcohol-Sulphuric Acid-Methanol-Hydrochloric Acid-Acetone- Camphor sulfonic acid-Sodium Bicarbonate.

Manufacturing Process of Clopidogrel

The extensive Clopidogrel production cost report consists of the following major industrial manufacturing process:

• From 2-Chlorobenzyl cyanide, Bromine, 4,5,6,7-tetrahydrothieno[3,2-c] pyridine hydrochloride, KOH, isopropyl alcohol, Sulphuric Acid, methanol, Hydrochloric Acid, acetone, camphor sulfonic acid, and sodium bicarbonate: Synthesis of Clopidogrel is a multistep process in the industrial arena. 2-chlorobenzyl cyanide is brominated by Bromine to produce an α-bromo-2-chlorobenzyl cyanide intermediate. The intermediate obtained then undergoes nucleophilic substitution and cyclization with 4,5,6,7-tetrahydrothieno[3,2-c] pyridine hydrochloride. It constitutes the core structure of thienopyridine with a 2-chlorophenyl group attached. This nitrile is hydrolyzed to a carboxylic acid. The acid is next esterified using a combination of sulphuric acid, methanol, hydrochloric acid, and acetone to yield methyl esters. Then, the ester is treated using hydrochloric acid (or camphor sulfonic acid) along with sodium bicarbonate to obtain Clopidogrel hydrogen sulfate.

Clopidogrel is a white to off-white powder. Its molecular formula is C16H16Cl NO2S, and it has a molecular weight of 321.82 g/mol. It has a density of around 1.317 g/cm³ and a boiling point of around 423.7 ± 45.0 °C. It is insoluble in water, having a neutral pH, but shows good solubility at a pH value of 1. It is easily soluble in methanol and insoluble in ethyl ether. It has 0 hydrogen bond donors and four rotatable bonds. Its topological polar surface area is 57.78 Ų, and its partition coefficient value is (LogP) 2.73. These physical and chemical properties are essential for its pharmacological applications.