Dexrazoxane Production Cost Reports

The report provides a detailed analysis essential for establishing a Dexrazoxane manufacturing plant. It encompasses all critical aspects necessary for Dexrazoxane production, including the cost of Dexrazoxane production, Dexrazoxane plant cost, Dexrazoxane production costs, and the overall Dexrazoxane manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Dexrazoxane production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Dexrazoxane is utilized mostly in oncology, where it is used for patients taking doxorubicin for breast cancer to reduce the cardiotoxicity of anthracycline chemotherapy. In patients who receive high doses of these chemotherapeutics, it serves as a cardio-protective drug to help avoid heart dysfunction and cardiomyopathy. In addition, extravasation, which is a situation when chemotherapy leaks to the surrounding tissues when administered through a vein, is treated with Dexrazoxane. The efficacy of the medication has been shown, and it has been proven that heart failure is reduced in terms of both its frequency and severity without compromising the effectiveness of the chemotherapy. It has very recently attracted attention for potential off-label applications, like treatment of neurodegenerative diseases like Parkinson’s disease.

The market for Dexrazoxane is driven by its application in oncology, especially for breast cancer, which elevates its demand in the pharmaceutical and medical industries. The rising cases of cancer also increase the demand for drugs like Dexrazoxane. Its ability to mitigate the cardiotoxic effects caused by anthracycline chemotherapy drugs amplifies its demand in oncology. Its efficacy in treating extravasation boosts its demand even further. The drug’s employment in off-label applications, like managing of Parkinson’s disease, adds to the product’s market value.

Overall, industrial Dexrazoxane procurement is influenced by its application in oncology, the rising cases of cancer, its ability to mitigate cardiotoxic effects of other chemotherapy drugs, its efficacy in treating conditions such as extravasation, its employment in off-label conditions, regulatory approvals, development of healthcare infrastructure, and advancements in medical research.

Raw Material for Dexrazoxane Production

According to the Dexrazoxane manufacturing plant project report, the key raw material used in the production of Dexrazoxane includes 1,2-diaminopropane.

Manufacturing Process of Dexrazoxane

The extensive Dexrazoxane production cost report consists of the following major industrial manufacturing process:

• Production from 1,2-diaminopropane: The manufacturing process of Dexrazoxane starts with the reaction of racemic 1,2-diaminopropane with D-tartaric acid to form a chiral diamine. The diamine is subjected to alkylation with chloroacetic acid in the presence of NaOH in water to give a tetraacid. Finally, the tetraacid undergoes cyclization in hot formamide to produce Dexrazoxane.

Dexrazoxane is a white crystalline powder having the molecular formula C11H16N4O4 and a molecular weight of 268.27 g/mol. It has a melting point in the range of 191-197 °C. It has a water solubility of 10-12 mg/mL at 25 °C. It dissolves to some extent in methanol and ethanol but does not dissolve in non-polar organic solvents. It has an estimated vapor pressure of 2.0X10-15 mm Hg at 25 °C. The value of its partition coefficient, log P, is -2.6. The value of its dissociation constant, pKa, is 2.1.