Diltiazem Production Cost Reports

The report provides a detailed analysis essential for establishing a Diltiazem manufacturing plant. It encompasses all critical aspects necessary for Diltiazem production, including the cost of Diltiazem production, Diltiazem plant cost, Diltiazem production costs, and the overall Diltiazem manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Diltiazem production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Diltiazem is an FDA-approved drug that finds huge applications in the medical and pharmaceutical industries. It is widely utilized as a calcium channel blocker in the treatment of hypertension (high blood pressure), angina (chest pain), and certain types of arrhythmias (irregular heartbeats). Moreover, it also finds its application as a cardiovascular drug for the treatment of various cardiovascular conditions by blocking calcium channels in the heart and blood vessels to improve blood flow. Additionally, it is also used to relieve migraine prophylaxis, pulmonary hypertension, and rest-related cramps in the lower extremities.

The demand for Diltiazem is majorly driven by its utilization as a potent vasodilator compound that is used for the treatment of stable and nonstable angina pectoris and cardiovascular conditions, which significantly boosts its market growth. Its utilization as an oral drug for the treatment and management of angina pectoris, chronic stable angina, atrial fibrillation, and atrial flutter further enhances its demand in the medical and pharmaceutical industries.

Moreover, its huge employment as an antihypertensive agent for the treatment of hypertension (high blood pressure) remarkably promotes its demand in the medical and healthcare industries. Additionally, variations in its cost and the availability of raw materials (methylchoroacetate, etc.), regulatory compliance, and pharmaceutical regulations play an important role in outlining procurement guidelines. Moreover, technological advancements in the production process, supplier reliability, sustainability practices, and efficient logistics largely impact industrial diltiazem procurement globally.

Raw Material for Diltiazem Production

According to the Diltiazem manufacturing plant project report, the major raw materials for Diltiazem production include 4-Methoxybenzaldehyde-Methylchoroacetate-Sodium Methoxide-2-Aminothiophenol-Acetic Anhydride/Dimethylformamide/Pyridine-2,2-Dimethylaminoethylchloride.

Manufacturing Process of Diltiazem

The extensive Diltiazem production cost report consists of the following industrial manufacturing process:

1. Production via Condensation: This method of production is initiated by the condensation of 4-methoxybenzaldehyde with methylchoroacetate in the presence of sodium methoxide to form methyl ester of 3-(4-methoxyphenyl)-glycidylic acid, followed by its epoxidation by reacting it with 2-aminothiophenol to give methyl ester of 2-hydroxy-3-(2′-aminophenylthio)-3- (4″-methoxyphenyl)propionic acid. Further, the obtained compound undergoes hydrolysis with alkali to form a racemic mixture of the corresponding acid, which on interaction with (+)-α-phenylethylamine, produces threo-(+)-2-hydroxy-3-(2′-aminophenylthio)-3-(4″-methoxyphenylpropionic acid. Then, the obtained compound is boiled in a mixture of acetic anhydride/dimethylformamide/pyridine, which facilitates the cyclization of the thiazepine ring and acrylates the hydroxyl group to produce (+)-cis-2-(4-methoxyphenyl)-3-acetoxy-2,3-dihydro-1,5-benzothiazepin-4-(5H)-one. Further, the obtained compound undergoes alkylation with 2,2-dimethylaminoethylchloride to obtain diltiazem as the final product.

Diltiazem is a derivative of benzothiazepine. It serves as a drug that has antihypertensive and vasodilating properties. The molecular formula of the compound is C22H26N2O4S, and its molecular weight is 414.5 g/mol. Moreover, the compound is also known as Dilcontin or Cardizem. The melting point and the boiling point of the compound are 212°C and 594.4 °C, respectively. It exists in the form of a white solid that is stored in a freezer at the temperature of -20°C. Additionally, the compound is typically available in the form of intravenous formulations and oral tablets. It is slightly soluble in chloroform, DMSO, and methanol.