Docetaxel Production Cost Reports

The report provides a detailed analysis essential for establishing a Docetaxel manufacturing plant. It encompasses all critical aspects necessary for Docetaxel production, including the cost of Docetaxel production, Docetaxel plant cost, Docetaxel production costs, and the overall Docetaxel manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Docetaxel production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Docetaxel is a chemotherapy medication used to treat a number of advanced or metastatic malignancies, such as those of the stomach, head and neck, lung, breast, and prostate. Depending on the type and stage of cancer, it can be used either alone or in conjunction with other chemotherapy medications such as doxorubicin, cyclophosphamide, cisplatin, fluorouracil, and prednisone. It acts by preventing cancer cells from proliferating, which results in their death.

The procurement of Docetaxel is influenced by its application in the pharmaceutical and medical industries as a chemotherapy medication. The use of Docetaxel has been demanded more since cases of stomach, head and neck, lung, breast, and prostate cancers are rising. In patients with metastatic cancer, Docetaxel is particularly useful in preventing progression and prolonging survival because of its strong tolerability profile.

In high-risk patients, it significantly improves survival rates. It is a standard adjunct medication in the treatment of breast cancer. Lastly, Docetaxel completes the triple-agent combination therapy known as the TEX regimen and is recommended for the treatment of advanced gastric cancer when combined with oxaliplatin and capecitabine. Overall, industrial Docetaxel procurement is influenced by its application in the pharmaceutical and medical industries as a chemotherapy medication, its wide range of applications, its use with other anti-cancer drugs, better tolerability, fewer side effects, high efficacy, and regulatory approvals.

Raw Material for Docetaxel Production

According to the Docetaxel manufacturing plant project report, the key raw material used in the production of Docetaxel includes benzaldehyde.

Manufacturing Process of Docetaxel

The extensive Docetaxel production cost report consists of the following major industrial manufacturing process:

• Production from benzaldehyde: The manufacturing process of Docetaxel starts with the reaction of benzaldehyde with 1-Phenylethylamine to form an intermediate, which is treated with acetoxyacetyl chloride to form an intermediate propiolactam. After the propiolactam is resolved by hydrolyzing the hydroxy group, the compound is recrystallized in a 7:1 combination of ethyl acetate and n-hexane to form another intermediate. The intermediate is subjected to catalytic hydrogenation by treating with HCl in the presence of Pd/MgCO3 or Pd/C to form another intermediate. The amino group is protected to form Methyl 2-Hydroxy-3-(N-tert-butoxycarbonyl)amino-3-phenylpropionate, which undergoes cyclization to protect the amino and hydroxy group to give Methyl N-tert-Butoxycarbonyl-2-(4'-methoxy)-phenyl-4-phenyl-1,3-oxazolidine-5- methionate. The ester is hydrolyzed in the presence of aq. KOH and MeOH to form the side chain of Docetaxel, which is finally reacted with the parent ring in the presence of Zn, AcOH, and MeOH as catalysts to form Docetaxel.

Docetaxel, commercially known as Docivyx and Taxotere, is a white powder having the molecular formula C43H53NO14 and a molecular weight of 807.9 g/mol. It has a melting point of around 232°C. It is highly lipophilic, being almost insoluble in water. It has a log P value of 2.4. The value of its dissociation constant, pKa, is 11.9. It is an antineoplastic medication used to treat a number of cancers.