Dofetilide Production Cost Reports
Healthcare
The report provides a detailed analysis essential for establishing a Dofetilide manufacturing plant. It encompasses all critical aspects necessary for Dofetilide production, including the cost of Dofetilide production, Dofetilide plant cost, Dofetilide production costs, and the overall Dofetilide manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Dofetilide production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.
Dofetilide is an FDA-approved class III antiarrhythmic agent that finds its major applications in the medical and pharmaceutical sectors. It is widely used as an anti-arrhythmia drug in the treatment and prevention of atrial fibrillation and atrial flutter. It is also utilized as an oral drug in the maintenance of sinus rhythm in individuals at risk of forming atrial fibrillation and flutter. It also finds its application as a subject for ongoing research in the pharmaceutical field in studies related to cardiac disorders and new applications for treating other types of arrhythmias.
The demand for Dofetilide is primarily driven by its application as an FDA-approved antiarrhythmic agent in the production of antiarrhythmic medications, which largely promotes its market. Its utilization as an oral drug for the prevention and treatment of atrial fibrillation and atrial flutter also fuels its demand in the pharmaceutical and healthcare industries. Its involvement as a subject in the medical research and development industry for studies related to the treatment of life-threatening cardiac conditions and several types of arrhythmias further boosts its market growth.
The synthesis of Dofetilide requires specialized knowledge and facilities that adhere to Good Manufacturing Practices (GMP). Thus, any disruptions in manufacturing, such as equipment failures or supply shortages of raw materials, greatly affect the production and overall procurement process of Dofetilide. Additionally, fluctuations in the demand for Dofetilide from downstream industries, such as pharmaceutical, healthcare, and medical, further impact the pricing and industrial Dofetilide procurement.
Raw Material for Dofetilide Production
According to the Dofetilide manufacturing plant project report, the major raw materials for Dofetilide production include 4-(2-bromoethoxy)methanesulfonanilide and N-methyl-p-nitrophenethylamine and Dimethyl Sulfate.
Manufacturing Process of Dofetilide
The extensive Dofetilide production cost report consists of the following industrial manufacturing process:
- Production via Chemical Synthesis: This method of production involves the synthesis of Dofetilide by using 4-(2-bromoethoxy)methanesulfonanilide, N-methyl-p-nitrophenethylamine, and potassium carbonate as the raw materials. The process starts with the reaction of 4-(2-bromoethoxy)methanesulfonanilide is reacted with N-methyl-p-nitrophenethylamine in the presence of potassium carbonate in a solvent called acetonitrile. Further, the nitro group (a part of the molecule containing nitrogen and oxygen) in the newly formed compound is converted into an amine group (which contains just nitrogen and hydrogen) through catalytic reduction. In the final step, the amine group formed is treated with dimethyl sulfate in methylene chloride to obtain Dofetilide as the final product.
Dofetilide is a tertiary amino compound that exits in the form of a white to off-white crystalline powder with the molecular formula C19H27N3O5S2. Its molecular weight is 441.6 g/mol. The compound has a melting point of 260-266°C, and it also gets decomposed at this temperature. The compound is very slightly soluble in water and propan-2-ol, but soluble in 0.1M aqueous sodium hydroxide, acetone, and aqueous hydrochloric acid. Dofetilide has a LogP value of 1.8, and its pKa value is 8.99. Its topological polar surface area is 122 Ų. It is highly bioavailable (>90%) when administered orally, with peak plasma concentrations occurring at about 2-3 hours in the fasted state. It is generally sold under the brand name Tikosyn.
Product Details
| Particulars | Details |
|---|---|
| Product Name | Dofetilide |
| Scope | Manufacturing Process: Process Flow, Material Flow, Material Balance Raw Material and Product Specifications: Raw Material Consumption, Product and Co-product Generation Land and Site Cost: Offsites/Civil Works, Equipment Cost, Auxiliary Equipment Costs, Contingency, Engineering and Consulting Charges, Working Capital Variable Cost: Raw Material, Utilities, Other Variable Costs Fixed Cost: Labor Requirements and Wages, Overhead Expenses, Maintenance Charges, Other Fixed Costs Financing Costs: Interest on Working Capital, Interest on Loans Other Costs: Depreciation Charges, General Sales and Admin Cost |
| Currency | US$ (Data can also be provided in the local currency) |
| Pricing and Purchase Options | Basic: US$ 2499 Premium: US$ 3499 Enterprise: US$ 4799 |
| Customization Scope | The report can be customized as per the requirement of the customer |
| Post-Sale Analysts Report | 10-12 weeks of post-purchase analyst support after report delivery for any queries from the deliverable |
| Delivery Format | PDF and Excel format through email (editable version in PPT/Word format of the report can be also provided on special request) |
How does our Dofetilide Production Cost Report Provide Exhaustive Data and Extensive Insights?
At Procurement Resource, we not only focus on optimizing the should cost of production for Dofetilide but also provide our clients with extensive intel and rigorous information on every aspect of the production process. By utilizing a comprehensive cost model, we help you break down expenses related to raw materials, labor, and technology, offering clear pathways to savings. We also assist in evaluating the capital expenditure (CAPEX) and operating expenses (OPEX), which are often measured as cost per unit of production, such as USD/MT, ensuring that your financial planning is aligned with industry benchmarks.
We offer valuable insights on the top technology providers, in-depth supplier database, and best manufacturers, helping you make informed decisions to improve efficiency. Additionally, we design the most feasible layout for your production needs, ensuring the entire process runs smoothly. By minimizing the cash cost of production, we ensure that you stay competitive while securing long-term profitability in the growing Dofetilide market. Partnering with Procurement Resource guarantees that every aspect of your production is cost-efficient, advanced, and tailored to your specific requirements.
Key Questions Answered in This Report
- What are the key requirements for setting up a Dofetilide manufacturing plant?
- How is Dofetilide manufactured?
- What is the process flow involved in producing Dofetilide?
- What are the raw material requirements and costs for producing Dofetilide?
- What is the total size of land required for setting up a Dofetilide manufacturing plant?
- What are the construction requirements for setting up a Dofetilide manufacturing plant?
- What are the machinery requirements for producing Dofetilide?
- What are the utility requirements and costs for producing Dofetilide?
- What are the manpower requirements for producing Dofetilide?
- What are the average salaries/wages of manpower working in a Dofetilide manufacturing plant?
- What are the packaging requirements and associated costs for Dofetilide?
- What are the transportation requirements and associated costs for Dofetilide?
- What are the capital costs for setting up a Dofetilide manufacturing plant?
- What are the operating costs for setting up a Dofetilide manufacturing plant?
- What should be the price of Dofetilide?
- What will be the income and expenditures for a Dofetilide manufacturing plant?
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