Domperidone Production Cost Reports

The report provides a detailed analysis essential for establishing a Domperidone manufacturing plant. It encompasses all critical aspects necessary for Domperidone production, including the cost of Domperidone production, Domperidone plant cost, Domperidone production costs, and the overall Domperidone manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Domperidone production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Domperidone is a peripheral dopamine antagonist that is primarily utilized in the pharmaceutical industry for its antiemetic and gastroprokinetic properties. It is widely used as an anti-sickness medicine to treat nausea and vomiting associated with various conditions, including migraine, gastroparesis, and medication-induced nausea. It also finds its application as a medicine in alleviating the symptoms in patients undergoing treatment for Parkinson's disease. The medication helps ease the feeling of being sick or nauseous. It also finds its application as a medication for the treatment of gastrointestinal issues in animals and is specifically approved for preventing fescue toxicosis in mares. It is sometimes used off-label to enhance breast milk production by increasing prolactin levels.

The market for Domperidone is majorly led by its applications as a drug used for the treatment of nausea. Its utilization as an antiemetic drug for the short-term treatment of vomiting and nausea, along with other related symptoms, further enhances its demand in the medical and pharmaceutical industries. Its involvement as a medication in the treatment and management of gastrointestinal problems in animals also contributes to its demand in the veterinary medicine industry. Any disruptions in the supply of high-quality raw materials necessary for the synthesis of Domperidone directly impact its production, availability, and industrial Domperidone procurement. Additionally, compliance with international pharmaceutical standards (such as GMP - Good Manufacturing Practices) due to concerns over potential side effects also impacts its procurement strategies.

Raw Material for Domperidone Production

According to the Domperidone manufacturing plant project report, the major raw materials for Domperidone production include Orthophenylene Diamine-Methyl Aceto Acetate.

Manufacturing Process of Domperidone

The extensive Domperidone production cost report consists of the following industrial manufacturing process:

• Production from Orthophenylene Diamine: This method of production involves multiple steps for the synthesis of Domperidone as the final product. The process begins with the condensation of orthophenylene diamine with methyl aceto acetate in xylene, followed by dissolving in Lye solution and reprecipitating with hydrochloric acid. Further, the obtained compound is reacted with 1-bromo-3- chloro- propane in toluene in the presence of anhydrous potassium carbonate, followed by the addition of water and separation of the toluene layer to obtain domperidone as the final product.

Domperidone is a heteroarylpiperidine and an oral drug that belongs to the family of benzimidazoles. The molecular formula of the compound is C22H24ClN5O2. Its molar mass is 425.9 g/mol. The melting point of the compound is around 242.5 °C, and its solubility in water is 0.986 mg/L. It exists in the form of an odorless, white, or almost white crystalline powder that remains a solid at room temperature. Its value of pka is 7.90. The drug is known to have multiple side effects like dry mouth, diarrhea, nausea, abdominal cramps, rash, itching, and hyperprolactinemia. The drug is sold under the brand name Motilium. Additionally, it is recommended to store the compound at room temperature.