Encorafenib Production Cost Reports
Healthcare
The report provides a detailed analysis essential for establishing an Encorafenib manufacturing plant. It encompasses all critical aspects necessary for Encorafenib production, including the cost of Encorafenib production, Encorafenib plant cost, Encorafenib production costs, and the overall Encorafenib manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Encorafenib production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.
Encorafenib is used to treat advanced melanoma, a dangerous kind of skin cancer. It is a member of the kinase inhibitor drug class. These medications function by preventing abnormal proteins from signaling to cancer cells to proliferate. It is also used in conjunction with another medication known as binimetinib. It is particularly effective for patients whose cancer has specific gene mutations known as BRAF V600E or V600K.
The market for Encorafenib is driven by its usage as an anticancer drug used for the treatment of melanoma, which significantly promotes its demand in the pharmaceutical and medical industries. The widespread occurrence of skin cancer is significantly increasing the demand for Encorafenib. The ability of Encorafenib to target specific gene mutations (BRAF), which are present in almost half the cases, amplifies its market appeal.
The drug’s utilization with binimetinib in a combination therapy further enhances its efficacy, thereby contributing to its market demand. Overall, industrial Encorafenib procurement is influenced by its application in the pharmaceutical and medical industries, rising cases of melanoma or skin cancer, ability to target specific gene mutations, increased efficacy in combination therapy, and regulatory approvals.
Raw Material for Encorafenib Production
According to the Encorafenib manufacturing plant project report, the key raw materials used in the production of Encorafenib include benzaldehyde- isopropylhydrazine hydrochloride.
Manufacturing Process of Encorafenib
The extensive Encorafenib production cost report consists of the following major industrial manufacturing process:
- Production from benzaldehyde and isopropylhydrazine hydrochloride: The manufacturing process of Encorafenib starts with the condensation reaction of benzaldehyde with isopropylhydrazine hydrochloride to form Schiff base. The Schiff base undergoes nucleophilic substitution reaction 2-(ethoxymethylene)malononitrile to give an intermediate. The intermediate is subjected to a cyclization reaction under acidic conditions to form pyrazole. The pyrazole undergoes nucleophilic addition reaction with methyl magnesium bromide to give ketone, which is iodinated and then subjected to aldol condensation with N,N-dimethylformamide (DMF) to give α,β-unsaturated ketone. The ketone is cyclized with guanidine hydrochloride to form pyrimidine. The amino group of the pyrimidine is further oxidized to alcohol. The alcohol undergoes chlorination reaction and subsequent substitution with amine to give another intermediate, which undergoes Suzuki coupling with borate ester to form the third intermediate. The Boc protective group is removed under acidic conditions to give the final intermediate. Finally, the intermediate undergoes sulfonylation and subsequent removal of the sulfonyl group to produce Encorafenib.
Encorafenib, commercially known as Braftovi, is a white crystalline powder having the molecular formula C22H27ClFN7O4S and a molecular weight of 540.0 g/mol. It has an estimated water solubility of 0.0112 mg/mL. It is slightly soluble in aqueous medium and insoluble at pH 3 or higher. It has a log P value of 4.16. The value of its dissociation constant, pKa, is 8.45. It is an oral RAF kinase inhibitor with anti-tumor effects used to treat melanoma or skin cancer.
Product Details
| Particulars | Details |
|---|---|
| Product Name | Encorafenib |
| Scope | Manufacturing Process: Process Flow, Material Flow, Material Balance Raw Material and Product Specifications: Raw Material Consumption, Product and Co-product Generation Land and Site Cost: Offsites/Civil Works, Equipment Cost, Auxiliary Equipment Costs, Contingency, Engineering and Consulting Charges, Working Capital Variable Cost: Raw Material, Utilities, Other Variable Costs Fixed Cost: Labor Requirements and Wages, Overhead Expenses, Maintenance Charges, Other Fixed Costs Financing Costs: Interest on Working Capital, Interest on Loans Other Costs: Depreciation Charges, General Sales and Admin Cost |
| Currency | US$ (Data can also be provided in the local currency) |
| Pricing and Purchase Options | Basic: US$ 2499 Premium: US$ 3499 Enterprise: US$ 4799 |
| Customization Scope | The report can be customized as per the requirement of the customer |
| Post-Sale Analysts Report | 10-12 weeks of post-purchase analyst support after report delivery for any queries from the deliverable |
| Delivery Format | PDF and Excel format through email (editable version in PPT/Word format of the report can be also provided on special request) |
How does our Encorafenib Production Cost Report Provide Exhaustive Data and Extensive Insights?
At Procurement Resource, we not only focus on optimizing the should cost of production for Encorafenib but also provide our clients with extensive intel and rigorous information on every aspect of the production process. By utilizing a comprehensive cost model, we help you break down expenses related to raw materials, labor, and technology, offering clear pathways to savings. We also assist in evaluating the capital expenditure (CAPEX) and operating expenses (OPEX), which are often measured as cost per unit of production, such as USD/MT, ensuring that your financial planning is aligned with industry benchmarks.
We offer valuable insights on the top technology providers, in-depth supplier database, and best manufacturers, helping you make informed decisions to improve efficiency. Additionally, we design the most feasible layout for your production needs, ensuring the entire process runs smoothly. By minimizing the cash cost of production, we ensure that you stay competitive while securing long-term profitability in the growing Encorafenib market. Partnering with Procurement Resource guarantees that every aspect of your production is cost-efficient, advanced, and tailored to your specific requirements.
Key Questions Answered in This Report
- What are the key requirements for setting up an Encorafenib manufacturing plant?
- How is Encorafenib manufactured?
- What is the process flow involved in producing Encorafenib?
- What are the raw material requirements and costs for producing Encorafenib?
- What is the total size of land required for setting up an Encorafenib manufacturing plant?
- What are the construction requirements for setting up an Encorafenib manufacturing plant?
- What are the machinery requirements for producing Encorafenib?
- What are the utility requirements and costs for producing Encorafenib?
- What are the manpower requirements for producing Encorafenib?
- What are the average salaries/wages of manpower working in an Encorafenib manufacturing plant?
- What are the packaging requirements and associated costs for Encorafenib?
- What are the transportation requirements and associated costs for Encorafenib?
- What are the capital costs for setting up an Encorafenib manufacturing plant?
- What are the operating costs for setting up an Encorafenib manufacturing plant?
- What should be the price of Encorafenib?
- What will be the income and expenditures for an Encorafenib manufacturing plant?
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