Enoxacin Production Cost Reports

The report provides a detailed analysis essential for establishing an Enoxacin manufacturing plant. It encompasses all critical aspects necessary for Enoxacin production, including the cost of Enoxacin production, Enoxacin plant cost, Enoxacin production costs, and the overall Enoxacin manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Enoxacin production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Enoxacin is used for adults (18 years and older) who have certain infections caused by bacteria. Specifically, it is indicated for uncomplicated gonorrhea, which is an infection that can affect the urethra or the cervix, and urinary tract infections. This medication targets the bacteria responsible for these infections, helping to clear them up and relieve symptoms.

The procurement of Enoxacin is influenced by its application in the pharmaceutical and medical industries to treat bacterial infections. The use of Enoxacin has been demanded more since cases of bacterial infections are rising. It is effective against Gram-positive and Gram-negative bacteria as well. Enoxacin may be effective against infection that may be resistant to other drugs of its class. Thus, Enoxacin can be considered as a valuable replacement for the antibacterial treatments because it is rather effective and administered orally, with minimum side effects experienced by patients.

It has a longer half-life time than norfloxacin or ciprofloxacin and higher concentration of plasma and in tissues hence the higher demand. It also has been reported to possess encouraging anti-cancer activity. Overall, industrial Enoxacin procurement is influenced by its application in the pharmaceutical and medical industries, rising cases of bacterial infections, broad-spectrum, well tolerability, fewer side effects, increasing healthcare awareness, and regulatory approvals.

Raw Material for Enoxacin Production

According to the Enoxacin manufacturing plant project report, the key raw material used in the production of Enoxacin includes 2,6-dichloro-3-nitropyridine.

Manufacturing Process of Enoxacin

The extensive Enoxacin production cost report consists of the following major industrial manufacturing process:

• Production from 2,6-dichloro-3-nitropyridine: The manufacturing process of Enoxacin starts with the reaction of the starting compound with N-ethoxycarbonylpiperazine to form an intermediate. The chlorine atom at the 6th place is replaced with an amino group. The amino group is then acylated using acetic anhydride. The nitro group is reduced at the C3 position of the pyridine ring with hydrogen to form another intermediate. A Schiemann reaction is performed to add a fluorine atom at position C3. The free amino group undergoes diazotization with amyl nitrite to give diazonium salt, which is treated with tetra-fluoroboric acid to form diazonium tetrafluoroborate. The compound is then subjected to pyrolysis to form 3-fluoro-6-acetylamino-2-(4-ethoxycarbonylpiperazinyl)pyridine. The acetyl protection of the amino group at position C6 is removed to form 3-fluoro-6-amino-2-(4-ethoxycarbonylpiperazinyl)pyridine. The amine is treated with ethyl ethoxymethylenmalonate to form a derivative of aminomethylenmalonic ester. The ester is heated to give the ethyl ester of the final intermediate. Finally, the compound is alkylated with ethyl iodide followed by hydrolysis of the two carboethoxy groups to produce Enoxacin.

Enoxacin, commercially known as Penetrex, is a white to off-white crystalline powder, having the molecular formula C15H17FN4O3 and a molecular weight of 320.32 g/mol. It has a melting point in the range of 220-224 °C. It has a water solubility of 3.43 g/L and an estimated water solubility of 1.09 mg/mL. Enoxacin is a broad-spectrum antibiotic used to treat bacterial infections mainly gonorrhea and urinary tract infections.