Etorphine Production Cost Reports

The report provides a detailed analysis essential for establishing an Etorphine manufacturing plant. It encompasses all critical aspects necessary for Etorphine production, including the cost of Etorphine production, Etorphine plant cost, Etorphine production costs, and the overall Etorphine manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Etorphine production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Etorphine is a medication used in veterinary medicine. It is primarily utilized to help immobilize large animals, like elephants or other big mammals, for medical procedures or transportation. Because it is very powerful, it is not used for humans and is specifically designed for the care of animals. Etorphine is a morphinan alkaloid, a narcotic, and an analgesic. It functions as an agonist of the opioid receptor, a sedative, and an opioid analgesic.

The procurement of Etorphine is influenced by its utilization as a sedative in the veterinary industry to immobilize large animals for medical purposes, transportation, and conservation purposes. It is more powerful than morphine, thereby proving as a better option for veterinarians and researchers, which contributes to its demand. Moreover, its high potency allows sufficient doses to be administered to large wild animals via dart guns, which significantly accelerates its demand.

Additionally, the ability of Etorphine and its antidote, diprenorphine, to act very quickly enables rapid immobilization and reversal, making it superior to other drugs of its class, which amplifies its market appeal. Furthermore, there are limited alternatives to Etorphine for safely and effectively immobilizing very large mammals, which makes it the preferred choice for veterinarians. Overall, industrial Etorphine procurement is influenced by its utilization in the veterinary industry as a sedative, greater potency than morphine, quick onset of action, limited alternatives to the medication, and regulatory approvals.

Raw Material for Etorphine Production

According to the Etorphine manufacturing plant project report, the key raw material used in the production of Etorphine includes codeine.

Manufacturing Process of Etorphine

The extensive Etorphine production cost report consists of the following major industrial manufacturing process:

• Production from Codeine: The manufacturing process of Etorphine starts with the N-carboethoxylation of the tertiary amine of codeine by using ethylchloroformate in the presence of potassium carbonate in chloroform to form N-carboethoxycodeine. In the next step, the compound is subjected to Swern oxidation to form the α,β-unsaturated ketone. The carbonyl group of the ketone is further converted to the vinyl methyl ether by reacting it with potassium tert-butoxide and dimethyl sulfate to form an intermediate. The ethyl carbamate is reduced by LiAlH4 to give thebaine. Thebaine undergoes a Diels-Alder reaction with methyl vinyl ketone to form an adduct. The adduct is treated with Grignard reagent (PrMgBr) to form an alcohol. Finally, the alcohol is subjected to demethylation to produce Etorphine.

Etorphine, commercially known as Immobilon (combination with acepromazine or methotrimeprazine), appears as a white to off-white crystalline solid having the molecular formula C25H33NO4 and a molecular weight of 411.5 g/mol. It has a melting point in the range of 214-217 °C. It has a log P value of 2.79. It releases poisonous nitrogen oxide fumes when heated to decompose. It has an estimated water solubility of 0.112 mg/mL. The value of its dissociation constant, pKa, is 10.21. It is classified as a narcotic analgesic morphinan used as a sedative in the veterinary industry.