Fosphenytoin Sodium Production Cost Reports

The report provides a detailed analysis essential for establishing a Fosphenytoin Sodium manufacturing plant. It encompasses all critical aspects necessary for Fosphenytoin Sodium production, including the cost of Fosphenytoin Sodium production, Fosphenytoin Sodium plant cost, Fosphenytoin Sodium production costs, and the overall Fosphenytoin Sodium manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Fosphenytoin Sodium production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Fosphenytoin Sodium is a water-soluble prodrug that acts as an anticonvulsant and has primary applications in the medical industry. It is widely used as an oral drug for the treatment of epileptic seizures. Moreover, it also finds its application in the treatment and prevention of seizure activity that occurs during neurosurgery, as it reduces cell excitability.

The demand for Fosphenytoin Sodium is largely driven by its application in the medical industry as an antiepileptic agent for the management of seizures in epilepsy, which significantly boosts its market expansion. Its employment as a drug to prevent seizures and reduce their severity in patients during brain surgery further enhances its demand in the medical, healthcare, and pharmaceutical industries. Additionally, several key factors, which include the cost and availability of raw materials (phenytoin, etc.), compliance with healthcare regulations, and maintaining quality standards, significantly influence industrial Fosphenytoin Sodium procurement to a large extent.

Raw Material for Fosphenytoin Sodium Production

According to the Fosphenytoin Sodium manufacturing plant project report, the major raw materials for Fosphenytoin Sodium production include Phenytoin-Formadehyde.

Manufacturing Process of Fosphenytoin Sodium

The extensive Fosphenytoin Sodium production cost report consists of the following industrial manufacturing process:

1. Production from Phenytoin: This method of production is initiated by the reaction of 5,5-Diphenylhydantoin (phenytoin) with formaldehyde in the presence of potassium Carbonate (K2CO3) in water to form 3-(hydroxymethyl)-5,5-diphenylhydantoin. Further, the obtained compound is reacted with PCl3 in dichloromethane to give 3-(chloromethyl)-5,5-diphenylhydantoin, followed by its condensation with silver dibenzyl phosphate in refluxing benzene to obtain dibenzyl 5,5-diphenylhydantoin-3-ylmethyl phosphate. Then, the obtained compound further undergoes reduction with H2 in the presence of Pd/C in ethyl acetate to give the corresponding free phosphoric acid, followed by its reaction with sodium hydroxide in methanol, which results in the formation of Fosphenytoin Sodium as the final product.

Fosphenytoin Sodium is the form of the sodium salt of fosphenytoin that serves as drug for treating seizures. It is majorly marketed under the trade name CEREBYX. Moreover, the molecular formula of the compound is C16H13N2Na2O6P, and its molecular weight is 406.24 g/mol. The compound exists in the form of white to-tan powder with a solubility of 15mg/mL in water. Additionally, the melting point of the compound is 220°C, and it is stored in an inert atmosphere at the temperature of 2-8°C.