Gemfibrozil Production Cost Reports

The report provides a detailed analysis essential for establishing a Gemfibrozil manufacturing plant. It encompasses all critical aspects necessary for Gemfibrozil production, including the cost of Gemfibrozil production, Gemfibrozil plant cost, Gemfibrozil production costs, and the overall Gemfibrozil manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Gemfibrozil production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Gemfibrozil is a drug that helps reduce elevated triglyceride levels in the blood and increase good cholesterol (HDL) by improving fat breakdown in the body. It activates a receptor that increases fat oxidation and decreases the synthesis of harmful lipoproteins. It is used to treat hypertriglyceridemia in patients of Types IV and V hyperlipidemia who are at risk for pancreatitis. Gemfibrozil also helps in decreasing the risk of coronary heart disease that fails to respond to other medications and diet control. It is employed in addition to dietary changes and useful for patients with extremely high triglycerides, as it can significantly decrease cholesterol and reduce overall risk.

The market for Gemfibrozil is driven by several components that include its growing demand for managing hyperlipidemia and associated cardiovascular illnesses among people. The rising cases of pancreatitis and coronary heart disease contribute to its growing demand among healthcare professionals. Its utilization in treating patients with severe hypertriglyceridemia further fuels its marketability. Its availability in multiple formulations and rising demand for preventive healthcare and the management of lipids further contribute to its demand. Its affordable pricing and availability of generic forms make it important for usage in dyslipidemia management. Overall, industrial Gemfibrozil procurement is affected by its ability to manage hyperlipidemia and cardiovascular diseases, along with rising cases of pancreatitis, availability in multiple formulations, and affordable pricing.

Raw Material for Gemfibrozil Production

According to the Gemfibrozil manufacturing plant project report, the key raw materials used in the production of Gemfibrozil include Lithium-Diisopropylamine-(2-Methylpropyl 2,2-Dimethylacetate)-(1-Bromo-Chloropropane)-( 2,5-Dimethylphenol).

Manufacturing Process of Gemfibrozil

The extensive Gemfibrozil production cost report consists of the following major industrial manufacturing process:

1. From Lithium, Diisopropylamine, (2-Methylpropyl 2,2-Dimethylacetate), 1-Bromo-Chloropropane, and 2,5-Dimethylphenol: The manufacturing of Gemfibrozil is a multi-step process. First, lithium is reacted with diisopropylamine, followed by adding 2-methylpropyl 2,2-dimethylacetate, forming an intermediate compound. After that, 1-bromo-3-chloropropane is added to the reaction mixture, forming the necessary intermediate for Gemfibrozil. This intermediate is then reacted with 2,5-dimethylphenol and sodium hydroxide, forming Gemfibrozil. Finally, the product is separated and purified to obtain pure Gemfibrozil.

Gemfibrozil is a white to off-white, odorless crystalline powder with a melting point between 57 and 62°C, insoluble in water and soluble in chloroform or acetone. It has limited solubility in water and a density of around 1.1109 g/cm³. It is electron-rich and acidic in nature, with a pKa value of around 4.75. It is freely soluble in dichloromethane and acetonitrile. Its solid-state stability largely depends on the ambient temperature, and it is stored between 2-8°C, as its decomposition behavior can vary under different temperatures. Its 70% dose is recovered as metabolites, mainly the glucuronide conjugate, with less than 0.1% excreted unchanged.