Glimepiride Production Cost Reports

The report provides a detailed analysis essential for establishing a Glimepiride manufacturing plant. It encompasses all critical aspects necessary for Glimepiride production, including the cost of Glimepiride production, Glimepiride plant cost, Glimepiride production costs, and the overall Glimepiride manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Glimepiride production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Glimepiride is an oral medicine that is used to treat type 2 diabetes, characterized by insufficient insulin production or ineffective use of insulin in the body, leading to elevated blood sugar levels. It lowers blood sugar levels by increasing the amount of insulin produced in the body. It finds its application mainly in the pharmaceutical industry as an oral medication to manage type 2 diabetes. It is used for patients in which glycemic index is not controlled by diet and lifestyle changes alone. It is also used in combination with other antidiabetic medications that include insulin, which helps in improving blood sugar management. In comparison to other sulfonylurea drugs, it is associated with a lower risk of hypoglycemia and has a few adverse cardiovascular effects. It is only available on prescription, and it comes in the form of tablets.

Industrial Glimepiride procurement is influenced by the rising cases of type 2 diabetes globally, and it is a significant driver for its market growth. Early diagnosis and increasing awareness have led to more people receiving appropriate treatment, which has contributed to the market expansion of medicines like Glimepiride. Also, increasing generic competition makes it more affordable for patients, potentially increasing demand and overall market size. Stringent regulatory standards and adherence to careful production are required to ensure safety for widespread public use. Innovations in pharmaceutical technologies are enhancing drug efficacy and patient compliance. All these factors collectively support the growth of the Glimepiride market.

Raw Material for Glimepiride Production

According to the Glimepiride manufacturing plant project report, the key raw materials used in the production of Glimepiride include Carbamate of 3-ethyl-4-methyl-1H-pyrrol-2(5H)-on and 4-(2-aminoethyl) benzenesulfonamide and Phenyl (trans-4-methyl cyclohexyl) Carbamate.

Manufacturing Process of Glimepiride

The extensive Glimepiride production cost report consists of the following major industrial manufacturing process:

• From Carbamate of 3-ethyl-4-methyl-1H-pyrrol-2(5H)-on, 4-(2-aminoethyl) benzenesulfonamide, and Phenyl (trans-4-methylcyclohexyl) carbamate: The manufacturing process of Glimepiride starts with the preparation of the carbamate of 3-ethyl-4-methyl-1H-pyrrol-2(5H)-one. After that, this carbamate is reacted with 4-(2-aminoethyl) Benzenesulfonamide, which forms sulfonamide as an intermediate compound. This sulfonamide is combined with phenyl (trans-4-methylcyclohexyl) carbamate to form Glimepiride as the final product.

Glimepiride has a molecular formula of C24H34N4O5S and a molecular weight of 490.62 g/mol. It appears white to yellowish-white, crystalline, odorless powder with high permeability and low solubility. Its logP value is 3.9, making it moderately lipophilic in nature.  It contains 3 hydrogen donor bonds and 5 hydrogen acceptor bonds with a topological polar surface area of 133 Ų. It belongs to the sulfonylurea class of drugs and has poor water solubility. Its chemical structure includes a sulfonamide group and a heterocyclic ring system. It contains functional groups like amide and aromatic groups, which contribute to its pharmacological activity.