Glyburide Production Cost Reports

The report provides a detailed analysis essential for establishing a Glyburide manufacturing plant. It encompasses all critical aspects necessary for Glyburide production, including the cost of Glyburide production, Glyburide plant cost, Glyburide production costs, and the overall Glyburide manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Glyburide production plant.

These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Glyburide is an antidiabetic medication used to treat type 2 diabetes in adults. It can be taken alone or combined with another diabetes drug called metformin. It works by helping the body produce more insulin, to control the blood glucose levels. It is a member of the class of drugs called second-generation sulfonylureas used to treat people with type II diabetes or non-insulin-dependent diabetes mellitus. It is usually used in individuals who are unresponsive to metformin, the first-line treatment.

The procurement of Glyburide is influenced by its application in the pharmaceutical and medical industries as an antidiabetic medication used to manage blood sugar levels. The widespread occurrence of type-2 diabetes is significantly increasing the demand for Glyburide. It witnesses a significant demand from the aging population as they are more likely to be affected by diabetes. The availability of Glyburide in combination with metformin also enhances its efficacy in controlling blood sugar levels, which amplifies its market presence.

Glyburide requires a relatively small dose compared to first-generation sulfonylureas, and dosing is usually a once-daily morning dose, which improves patient compliance and adherence to treatment, contributing to its market growth. Its activity on the sulfonylurea receptor 1 may help lower intracranial pressure and cerebral edema at modest doses. Researchers and medical professionals are interested in this new use of Glyburide because it broadens its therapeutic potential beyond the treatment of diabetes, thereby increasing its demand.

Glyburide has also been studied off-label for neonatal syndromic hyperglycemia, thus driving its market interest. Overall, industrial Glyburide procurement is influenced by its application in the pharmaceutical and medical industries as an antidiabetic medication, rising cases of diabetes mellitus, the aging population, combination therapy, convenient dosing regimens, off-label uses, and regulatory approvals.

Raw Material for Glyburide Production

According to the Glyburide manufacturing plant project report, the key raw material used in the production of Glyburide includes 2-methoxy-5-chlorobenzoic acid chloride.

Manufacturing Process of Glyburide

The extensive Glyburide production cost report consists of the following major industrial manufacturing process:

• Production from 2-methoxy-5-chlorobenzoic acid chloride: The manufacturing process of Glyburide starts with the reaction of the starting compound with 2-phenylethylamine to form an amide. The amide undergoes sulfonylchlorination by chlorosulfonic acid and further amination by ammonia to give sulfonamide. Finally, the resulting sulfonamide is treated with cylclohexylisocyanate to produce Glyburide.

Glyburide, commercially known as Diabeta, Glucovance, or Glynase, is a white crystalline powder having the molecular formula C23H28ClN3O5S and a molecular weight of 494.0 g/mol. It has a melting point of around 169 °C. It has a low water solubility in water. It has an estimated water solubility of 0.00206 mg/mL. It has a log P value of 3.754. The value of its dissociation constant, pKa, is 4.32. It is a member of second-generation sulfonylureas used to treat type-2 diabetes mellitus.