Grazoprevir Production Cost Reports
Healthcare
The report provides a detailed analysis essential for establishing a Grazoprevir manufacturing plant. It encompasses all critical aspects necessary for Grazoprevir production, including the cost of Grazoprevir production, Grazoprevir plant cost, Grazoprevir production costs, and the overall Grazoprevir manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Grazoprevir production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.
Grazoprevir is an antiviral medication used to treat Hepatitis C infection that affects the liver. It functions by preventing the hepatitis C virus from using specific proteins (NS3/4A proteases) to multiply and propagate throughout the body. Grazoprevir aids in preventing the virus from spreading and inflicting additional harm to the liver by blocking these proteins. Grazoprevir is mainly used in combination with another antiviral medication called elbasvir. This combination therapy, known as Zepatier, is highly effective in treating chronic hepatitis C infections, especially those caused by genotypes 1 and 4.
The procurement of Grazoprevir is influenced by its application in the pharmaceutical and medical industries as an antiviral medication used to treat Hepatitis C infection. The use of Grazoprevir has been demanded more since cases of Hepatitis C infections are rising. The combination of Grazoprevir and elbasvir shows a sustained virologic response (SVR), meaning the virus is no longer detectable in the blood in up to 99% of the patients. Most patients report minimal to no side effects from this well-tolerated medication.
Long-term health benefits of the medicine have been demonstrated, such as decreased risk of liver cancer, enhanced quality of life, decreased liver damage, and decreased overall mortality rates. Grazoprevir needs to be administered only once daily, which increases patient adherence. Overall, industrial Grazoprevir procurement is influenced by its application in the pharmaceutical and medical industries, rising cases of Hepatitis C infection, combination therapy, fewer side effects, better tolerability, patient adherence, long-term health benefits, increasing healthcare awareness, and regulatory approvals.
Raw Material for Grazoprevir Production
According to the Grazoprevir manufacturing plant project report, the key raw material used in the production of Grazoprevir includes (1R,2R)-2-(pent-4-yn-1-yl) cyclopropane-1-ol.
Manufacturing Process of Grazoprevir
The extensive Grazoprevir production cost report consists of the following major industrial manufacturing process:
- Preparation from (1R,2R)-2-(pent-4-yn-1-yl) cyclopropane-1-ol: The manufacturing process of Grazoprevir starts with the reaction of the starting compound with (S)-2-amino-3,3-dimethylbutanoic acid in the presence of N, N′-carbonyl diimidazole (CDI), N, N-diisopropylethylamine (DIPEA) to give an alkyne intermediate. The intermediate is subjected to Sonogashira cross-coupling with quinoxaline to form another intermediate. The triple bond in the intermediate undergoes hydrogenation to form the third intermediate. The intermediate undergoes deprotection with PhSO3H, followed by intramolecular condensation to form the final intermediate. Finally, the compound undergoes hydroxylation and condensation in the presence of ethyl dichloride, pyridine, and methyl cyanide to produce Grazoprevir.
Grazoprevir, commercially known as Zepatier (combination of Grazoprevir and elbasvir), appears to be a white to off-white solid having the molecular formula C38H50N6O9S and a molecular weight of 766.9 g/mol. It has limited water solubility of around 0.0108 mg/mL. It has a log P value of 3.26. The value of its dissociation constant, pKa, is 3.77. Adults with chronic HCV genotypes 1 or 4 infection are treated with azamacrocyclic drug Grazoprevir, a hepatitis C protease inhibitor.
Product Details
| Particulars | Details |
|---|---|
| Product Name | Grazoprevir |
| Scope | Manufacturing Process: Process Flow, Material Flow, Material Balance Raw Material and Product Specifications: Raw Material Consumption, Product and Co-product Generation Land and Site Cost: Offsites/Civil Works, Equipment Cost, Auxiliary Equipment Costs, Contingency, Engineering and Consulting Charges, Working Capital Variable Cost: Raw Material, Utilities, Other Variable Costs Fixed Cost: Labor Requirements and Wages, Overhead Expenses, Maintenance Charges, Other Fixed Costs Financing Costs: Interest on Working Capital, Interest on Loans Other Costs: Depreciation Charges, General Sales and Admin Cost |
| Currency | US$ (Data can also be provided in the local currency) |
| Pricing and Purchase Options | Basic: US$ 2499 Premium: US$ 3499 Enterprise: US$ 4799 |
| Customization Scope | The report can be customized as per the requirement of the customer |
| Post-Sale Analysts Report | 10-12 weeks of post-purchase analyst support after report delivery for any queries from the deliverable |
| Delivery Format | PDF and Excel format through email (editable version in PPT/Word format of the report can be also provided on special request) |
How does our Grazoprevir Production Cost Report Provide Exhaustive Data and Extensive Insights?
At Procurement Resource, we not only focus on optimizing the should cost of production for Grazoprevir but also provide our clients with extensive intel and rigorous information on every aspect of the production process. By utilizing a comprehensive cost model, we help you break down expenses related to raw materials, labor, and technology, offering clear pathways to savings. We also assist in evaluating the capital expenditure (CAPEX) and operating expenses (OPEX), which are often measured as cost per unit of production, such as USD/MT, ensuring that your financial planning is aligned with industry benchmarks.
We offer valuable insights on the top technology providers, in-depth supplier database, and best manufacturers, helping you make informed decisions to improve efficiency. Additionally, we design the most feasible layout for your production needs, ensuring the entire process runs smoothly. By minimizing the cash cost of production, we ensure that you stay competitive while securing long-term profitability in the growing Grazoprevir market. Partnering with Procurement Resource guarantees that every aspect of your production is cost-efficient, advanced, and tailored to your specific requirements.
Key Questions Answered in This Report
- What are the key requirements for setting up a Grazoprevir manufacturing plant?
- How is Grazoprevir manufactured?
- What is the process flow involved in producing Grazoprevir?
- What are the raw material requirements and costs for producing Grazoprevir?
- What is the total size of land required for setting up a Grazoprevir manufacturing plant?
- What are the construction requirements for setting up a Grazoprevir manufacturing plant?
- What are the machinery requirements for producing Grazoprevir?
- What are the utility requirements and costs for producing Grazoprevir?
- What are the manpower requirements for producing Grazoprevir?
- What are the average salaries/wages of manpower working in a Grazoprevir manufacturing plant?
- What are the packaging requirements and associated costs for Grazoprevir?
- What are the transportation requirements and associated costs for Grazoprevir?
- What are the capital costs for setting up a Grazoprevir manufacturing plant?
- What are the operating costs for setting up a Grazoprevir manufacturing plant?
- What should be the price of Grazoprevir?
- What will be the income and expenditures for a Grazoprevir manufacturing plant?
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