Guanfacine Production Cost Reports

The report provides a detailed analysis essential for establishing a Guanfacine manufacturing plant. It encompasses all critical aspects necessary for Guanfacine production, including the cost of Guanfacine production, Guanfacine plant cost, Guanfacine production costs, and the overall Guanfacine manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Guanfacine production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Guanfacine is a drug that is used to treat conditions such as attention deficit hyperactivity disorder and high blood pressure. It works by stimulating alpha-2 adrenergic receptors in the brain, leading to a reduction in nerve impulses from the vasomotor center present in our brain, which helps lower heart rate and blood pressure. It relaxes blood vessels, making it easier for blood to flow throughout the body. It is used alone or in combination with other medications to treat high blood pressure. It is generally taken as an extended-release tablet, which has a slower absorption rate and longer half-life, making it more suitable for children, too. It may cause adverse effects like sleepiness, fatigue, nausea, headache, low blood pressure, dry mouth, and constipation. Its application extends to treating other conditions, like anxiety and substance withdrawal.

The market for Guanfacine is driven by several factors. The growing cases of attention deficit hyperactivity disorder (ADHD) and other related disorders boost the demand for this medication. Its growing demand and cheaper costs because of advancements in technology contribute to its market growth. Its usage for treating other conditions like anxiety disorders and sleep disturbances expands its market growth. Government health policies aimed at improving mental health and hypertension management also play an important role in driving its demand. Altogether, these factors contribute to industrial guanfacine procurement around the globe.

Raw Material for Guanfacine Production

According to the Guanfacine manufacturing plant project report, the key raw materials used in the production of Guanfacine include (2,6-Dichlorophenylacetonitrile)-Sulfuric Acid-Methanol-Guanidine-Isopropanol.

Manufacturing Process of Guanfacine

The extensive Guanfacine production cost report consists of the following major industrial manufacturing process:

1. Production From 2,6-Dichlorophenylacetonitrile, Sulfuric Acid, Methanol, Guanidine, and Isopropanol: The manufacturing process of Guanfacine involves condensation reaction. In this process, 2,6-dichlorophenylacetonitrile reacts with sulfuric acid and methanol to form the intermediate 2,6-dichlorophenylacetate. This intermediate is then condensed with guanidine in isopropanol, yielding a crude product. Finally, the product is filtered, dried and processed to obtain Guanfacine as the final product.

Guanfacine has a molecular formula of C9H10Cl3N3O and a molecular weight of around 282.5 g/mol. It is a white to off-white crystalline powder which is sparingly soluble in water. It is soluble in methanol, slightly soluble in acetone, and insoluble in isopropanol and ethyl acetate. Its melting point is in the range of 213 °C to 217 °C. It has an oral bioavailability of approximately 80%, a half-life ranging from 10 to 30 hours, and it binds up to 70% to serum proteins. It is stable under normal storage conditions but needs to be kept away from strong oxidizing agents to prevent degradation. It may irritate mucous membranes and can be toxic if ingested in large amounts.