Indinavir Production Cost Reports

The report provides a detailed analysis essential for establishing a Indinavir manufacturing plant. It encompasses all critical aspects necessary for Indinavir production, including the cost of Indinavir production, Indinavir plant cost, Indinavir production costs, and the overall Indinavir manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Indinavir production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Indinavir is a potent HIV protease inhibitor that find its application in the medical and pharmaceutical industries. Moreover, it is mainly used an antiretroviral drug for the treatment of human immunodeficiency virus (HIV) infection. It also finds its application in combination with antiretroviral nucleoside analogues to treat both human immunodeficiency virus 1 and 2 in infected adults. Additionally, it is also employed as a medication for therapeutic treatment and prevention of HIV infection and the acquired immunodeficiency syndrome (AIDS).

The market for Indinavir is driven by its utilization as a therapy drug for the treatment of human immunodeficiency virus (HIV) infection, which significantly boosts its demand in the medical and pharmaceutical industries. Moreover, its employment as a combination medicine with other antiretroviral drugs for the treatment and prevention of (HIV) infection and the acquired immunodeficiency syndrome (AIDS) further enhances its demand in the pharmaceutical industries. Furthermore, several factors influence industrial Indinavir procurement, such as the availability of raw materials (Indene), cost and pricing, compliance with medical and pharmaceutical regulations, quality standards, technological advancements, environmental considerations, sustainability practices, distribution (including trading and shipping), logistics, safety standards, etc.

Raw Material for Indinavir Production

According to the Indinavir manufacturing plant project report, the major raw material for Indinavir production includes Indene.

Manufacturing Process of Indinavir

The extensive Indinavir production cost report consists of the following industrial manufacturing process:

• Production via Epoxidation of Indene: This method of production involves the technique of Jacobsen epoxidation of indene, followed by further processing to obtain indinavir as the final product. The epoxidation of indene initiates the process to form (1S,2R)-indene oxide by using (S,S)-(−)-N,N′-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminomanganese(III) chloride complex (0.7%) and 3% of 4-(3-phenylpropyl)pyridine N-oxide as auxiliary substances to provide stability to the catalyst and NaOCl as the terminal oxidant in chlorobenzene as a solvent that combinedly accelerates the process of epoxidation, resulting in 87% enantioselectivity. Further, the obtained product is converted to amino indanol through a stereospecific Ritter-type reaction by using MeCN/oleum, followed by the process of crystallization by using L-tartaric acid that promotes the enantioselectivity of the product, and results in the formation of indinavir as the desired product.

Indinavir is recognized as a synthetic hydroxyaminopentane amide drug that specifically restricts the protease of both human immunodeficiency virus 1 and 2. The molecular formula of Indinavir is C36H47N5O4, and its molecular weight is 613.8 g/mol. Moreover, the compound is also known as Crixivan. The melting point of the compound is 167.5-168 °C and is readily soluble in water and methanol. Additionally, the drug is available in the form of tablets and each of them is composed of sulfate salt along with anhydrous lactose and magnesium stearate. The drug is observed to have a bioavailability of 60%.