Indomethacin Production Cost Reports

The report provides a detailed analysis essential for establishing an Indomethacin manufacturing plant. It encompasses all critical aspects necessary for Indomethacin production, including the cost of Indomethacin production, Indomethacin plant cost, Indomethacin production costs, and the overall Indomethacin manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Indomethacin production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Indomethacin or indometacin is a potent non-steroidal anti-inflammatory drug (NSAID) known for its anti-inflammatory, antipyretic, and analgesic properties. It is widely used for the treatment of moderate to severe rheumatoid arthritis. Moreover, it is often utilized as an analgesic to relieve acute pain and inflammation associated with osteoarthritis, ankylosing spondylitis, gouty arthritis, and other musculoskeletal disorders in adults. Additionally, it is also employed as a drug to relieve headaches and migraine and is also effective in relieving pain in endodontic treatments.

The demand for Indomethacin is primarily driven due to its antipyretic, analgesic, and anti-inflammatory properties, which remarkably boosts its market expansion. Moreover, its usage as an anti-inflammatory drug for the treatment of chronic inflammatory arthritis, osteoarthritis, and acute painful shoulder (bursitis and tendinitis) further enhances its demand in the pharmaceutical industry. Its employment as a medication for relieving the symptoms of migraine and dental pain further promotes its market growth. Additionally, the cost of raw materials (sodium 2-(4-methoxy-phenyl)hydrazine-1-sulfonate, etc.), their availability and pricing, compliance with healthcare regulations, and maintaining quality standards serve as some of the major factors that greatly influence industrial Indomethacin procurement.

Raw Material for Indomethacin Production

According to the Indomethacin manufacturing plant project report, the major raw materials for Indomethacin production include Sodium 2-(4-methoxy-phenyl)hydrazine-1-sulfonate-4 and Chlorobenzoyl Chloride.

Manufacturing Process of Indomethacin

The extensive Indomethacin production cost report consists of the following industrial manufacturing process:

1. Production via Acylation: This method of production involves the process of acylation of sodium 2-(4-methoxy-phenyl)hydrazine-1-sulfonate, followed by further steps to synthesize indomethacin as the product. The process is initiated by the acylation of sodium 2-(4-methoxy-phenyl)hydrazine-1-sulfonate with 4-chlorobenzoyl chloride, followed by heating it to produce 1-(4- chlorobenzoyl)-1-(4-methoxyphenyl)hydrazine. Further, the obtained compound is subjected to Fischer indole synthesis through condensation by using levulinic acid, which results in the formation of indomethacin.

Indomethacin is a drug that belongs to the class of indole-3-acetic acids. The molecular formula of the compound is C19H16ClNO4, and its molar mass is 357.8 g/mol. Moreover, the compound is also known as Indometacin or Indocin. The IUPAC name of the compound is 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid. Additionally, the melting point of the compound ranges between 158-162 °C, and the boiling point of the compound is 499.4°C. The compound appears as a white or slightly yellow crystalline powder that is insoluble in water but gets easily dissolved in acetone, ethanol, chloroform, and ether. It is generally stored at room temperature. The density of the compound is 1.2135gm/cm3 and is light-sensitive.