Ivacaftor Production Cost Reports

The report provides a detailed analysis essential for establishing an Ivacaftor manufacturing plant. It encompasses all critical aspects necessary for Ivacaftor production, including the cost of Ivacaftor production, Ivacaftor plant cost, Ivacaftor production costs, and the overall Ivacaftor manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Ivacaftor production plant.

These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Ivacaftor is an aromatic amide and an FDA approve drug that finds specific applications in the medical industry. It is widely utilized as an oral drug for the treatment of cystic fibrosis in patients who have specific gene mutations in the CFTR gene. Moreover, it also finds its application as a medication used alone or in combination with another drug to manage cystic fibrosis (CF) in patients aged one month and older.

The market of Ivacaftor is largely led by its application as a drug for the management of cystic fibrosis (CF) in patients aged one month and older, which significantly promotes its demand in the pharmaceutical industry. Additionally, its employment in combination with other drugs to treat cystic fibrosis and a broader range of CFTR mutations further accentuates its demand in the medical and pharmaceutical industries.

Furthermore, several factors influence industrial Ivacaftor procurement, such as the availability of raw materials (4-Oxo-l,4-dihydro-quinoline-3-carboxylic acid, etc.), cost and pricing, compliance with pharmaceutical regulations, quality standards, technological advancements, environmental considerations, sustainability practices, distribution (including trading and shipping), logistics, safety standards, etc.

Raw Material for Ivacaftor Production

According to the Ivacaftor manufacturing plant project report, the major raw materials for Ivacaftor production include 4-Oxo-l,4-dihydro-quinoline-3-carboxylic Acid-2, 4 Ditertiary butyl-5-nitro- phenol.

Manufacturing Process of Ivacaftor

The extensive Ivacaftor production cost report consists of the following industrial manufacturing process:

• Production from 4-Oxo-l,4-dihydro-quinoline-3-carboxylic acid: This method of production is initiated by the reaction of 4-Oxo-l,4-dihydro-quinoline-3-carboxylic acid with 2, 4 ditertiary butyl-5-nitro- phenol in the presence of 0-Benzotriazole-N,N,N',N'-tetramethyl-uronium-hexafluoro-phosphate (HBTU) and triethyl amine, which results in the synthesis of Ivacaftor as the product. Further, the obtained compound is recrystallized with isopropyl alcohol to give pure Ivacaftor as the final product.

Ivacaftors is a quinolone and is also a member of phenols. It is an aromatic amide and a monocarboxylic acid amide that serves as a drug widely manufactured and distributed by Vertex Pharmaceuticals. The molecular weight of the compound is 392.5 g/mol, and its molecular formula is C24H28N2O3. Its dissociation constant value is pKa = 11.08. The compound is also considered as a potential endocrine disruptor. Moreover, the melting point of the compound is 212-215 degrees Celsius, and its boiling point is 550.4 degrees Celsius.

These physical and chemical properties of the compound contribute to its specific applications in the field of medical industry. Additionally, the density of the compound is 1.187g/cm3, and its flash point is 286.7°C. It is recommended to store the compound in a refrigerator. The compound is chemically known as N-(2,4-di-tert-butyl-5-hydroxyphenyl)-l,4-dihydro-4oxoquinoline-3-carboxamide.