Lasofoxifene Production Cost Reports

The report provides a detailed analysis essential for establishing a Lasofoxifene manufacturing plant. It encompasses all critical aspects necessary for Lasofoxifene production, including the cost of Lasofoxifene production, Lasofoxifene plant cost, Lasofoxifene production costs, and the overall Lasofoxifene manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Lasofoxifene production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Lasofoxifene is a non-steroidal oral drug with potential antineoplastic and anti-osteoporotic activities. It is a third-generation selective estrogen receptor modulator (SERM) that finds specific applications in the medical industry. Moreover, it is widely used for the treatment and prevention of postmenopausal osteoporosis in women by imitating estrogen impacts on bone tissue. Additionally, it also finds its application in the treatment of vaginal atrophy in women.

The market for Lasofoxifene is primarily driven by its application as an estrogen receptor agonist for the treatment of osteoporosis in postmenopausal women by preserving bone density, which significantly boosts its demand in the medical industry. Its utilization for preventing conditions associated with bone density and reducing the risk of both vertebral and nonvertebral fractures further enhances its demand in the medical and pharmaceutical industries.

Moreover, its employment as a drug for the treatment of vaginal atrophy symptoms and help with discomfort effectively accentuates its market expansion. Furthermore, several factors influence industrial lasofoxifene procurement, such as the availability and cost of production of its raw materials (acetophenone, pyrrolidine, etc.), cost and pricing, supplier relationships, quality standards, technological advancements, environmental considerations, sustainability practices, distribution (including trading and shipping), logistics, safety standards, etc.

Raw Material for Lasofoxifene Production

According to the Lasofoxifene manufacturing plant project report, the major raw material for Lasofoxifene production includes 3-Methoxy benzaldehyde- Acetophenone-4-(2-chloro ethoxy)benzoyl chloride- Titanium Trichloride-Pyrrolidine-DCM.

Manufacturing Process of Lasofoxifene

The extensive Lasofoxifene production cost report consists of the following industrial manufacturing process:

• Production via Intramolecular Reductive Coupling: This method of production is initiated by the process of aldol condensation between 3-methoxy benzaldehyde and acetophenone in the presence of potassium hydroxide to form chalcone, which is further subjected to hydrogenation in the presence of ethanol and Pd/C as a catalyst to give 3-(3-methoxyphenyl)-1-phenyl propane-1-one. Further, the obtained product undergoes Friedel– Crafts benzoylation with 4-(2-chloro ethoxy)benzoyl chloride to form a compound and a cyclized product, which are separated through reductive cyclization with titanium trichloride and Zn-Cu couple to synthesize a mixture of a cyclized product and the diaryl dihydronaphthalene compound. Then, the diaryl dihydronaphthalene compound is reacted with pyrrolidine to form nafoxidine, which is further converted to lasofoxifene on reaction with DCM, BBr3 to obtain lasofoxifene as the desired product.

Lasofoxifene belongs to the class of tetralins and is an aromatic ether. Its molecular formula is C28H31NO2, and its molecular weight is 413.5 g/mol. The IUPAC name of the compound is (5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol. It is regarded as an endocrine disruptor compound. Moreover, the compound is also recognized by the name Oporia. In postmenopausal women, the apparent oral clearance (CL/F) of lasofoxifene is around 6.6 l/hr. Additionally, the drug has a wide range of applications in the medical and pharmaceutical industries.