Levobupivacaine Production Cost Reports

The report provides a detailed analysis essential for establishing a Levobupivacaine manufacturing plant. It encompasses all critical aspects necessary for Levobupivacaine production, including the cost of Levobupivacaine production, Levobupivacaine plant cost, Levobupivacaine production costs, and the overall Levobupivacaine manufacturing plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Levobupivacaine production plant. These encompass manufacturing processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Levobupivacaine is an amino-amide local anesthetic medication that is primarily utilized in medical settings. It is widely used as a local anesthetic drug for surgery, obstetrics, and post-operative pain management to provide pain relief. Moreover, it also finds its application as an epidural for cesarean section during childbirth. Additionally, it is also employed as a pain relief medication for the management of pain during and after diagnostic and surgical procedures.

The market for Levobupivacaine is driven by its utilization for local or regional anesthesia in various medical procedures, which significantly boosts its demand in the medical industry. Its applications as an adrenergic antagonist to manage post-operative pain and pain associated with other surgical procedures further enhance its market expansion.

Furthermore, several factors influence industrial Levobupivacaine procurement, such as the availability of raw materials (l-Lysine, etc.), cost and pricing, compliance with medical & pharmaceutical regulations, quality standards, technological advancements, sustainability practices, distribution (including trading and shipping), logistics, safety standards, etc.

Raw Material for Levobupivacaine Production

According to the Levobupivacaine manufacturing plant project report, the major raw materials for Levobupivacaine production include l-Lysine-Sodium Nitrite (NaNO2)- Sodium acetate (NaOAc)-Acetic Acid.

Manufacturing Process of Levobupivacaine

The extensive Levobupivacaine production cost report consists of the following industrial manufacturing process:

• Production from l-Lysine: This method of production involves a five-step process of producing levobupivacaine as the product. The process is initiated by the reaction of Cbz l-Lysine with NaNO2 and NaOAc in acetic acid to give an intermediate (S)-6-acetoxy-2-(((benzyloxy)carbonyl)amino)hexanoic acid. Further, (S)-6-acetoxy-2-(((benzyloxy)carbonyl)amino)hexanoic acid and 2,6-xylidine undergo amide coupling through carbodiimide, which leads to the formation of another intermediate compound, (S)-5-(((benzyloxy)carbonyl)amino)-6-((2,6-dimethylphenyl)amino)-6-oxohexyl acetate.

Then, the reaction propagates through the acetoxy hydrolysis, followed by tosylation to give intermediate (S)-5-(((benzyloxy)carbonyl)amino)-6-((2,6-dimethylphenyl)amino)-6-oxohexyl 4-methylbenzenesulfonate. As the last step, the obtained intermediate is subjected to a one-pot deprotection/cyclization via catalytic hydrogenation in the presence of H2 and Pd/C to give an intermediate, which is further reacted with 1-bromobutane to obtain levobupivacaine as the final product.

Levobupivacaine belongs to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Moreover, the drug is widely marketed under the brand name Chirocaine. The chemical formula of the compound is C18H28N2O, and its molecular weight is 288.43 g/mol. The IUPAC name of the compound is (2S)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide. Additionally, the melting point of the compound is 136-137°C, and its boiling point is 430.65°C. Its density is around 1.0238g/cm3, and it is generally stored in a refrigerator.